Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer.
Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer.
复制标题
DOI：
10.1038/bjc.2013.673
复制
发表时间：
2014-01-07
影响因子：
8.8
通讯作者：
Ward, A. C.
中科院分区：
文献类型：
--
作者：
Kumar, J.;Fraser, F. W.;Riley, C.;Ahmed, N.;McCulloch, D. R.;Ward, A. C.
卵巢癌仍然是女性癌症死亡的主要原因，对疾病病因学在分子水平上的了解有限。粒细胞集落刺激因子(G-CSF)是正常和紧急造血的关键调节因子，临床上用于帮助包括卵巢癌在内的各种实体肿瘤的消融治疗后的造血恢复。检测G-CSF及其受体G-CSFR在卵巢癌组织和一组卵巢癌细胞系中的表达，探讨G-CSF对卵巢癌细胞增殖、迁移和生存的影响。G-CSFR主要在高级别浆液性卵巢上皮性肿瘤样本和卵巢癌细胞亚群中表达。用G-CSF刺激表达G-CSFR的卵巢上皮癌细胞，可增加细胞的迁移和存活，包括对抗化疗诱导的细胞凋亡。G-CSF的作用是通过JAK2/STAT3下游信号通路介导的。本研究提示G-CSF在卵巢癌的发病机制中具有潜在的作用，在确定合适的治疗方案时应考虑G-CSFR的表达状况。
Ovarian cancer remains a major cause of cancer mortality in women, with only limited understanding of disease aetiology at the molecular level. Granulocyte colony-stimulating factor (G-CSF) is a key regulator of both normal and emergency haematopoiesis, and is used clinically to aid haematopoietic recovery following ablative therapies for a variety of solid tumours including ovarian cancer. The expression of G-CSF and its receptor, G-CSFR, was examined in primary ovarian cancer samples and a panel of ovarian cancer cell lines, and the effects of G-CSF treatment on proliferation, migration and survival were determined. G-CSFR was predominantly expressed in high-grade serous ovarian epithelial tumour samples and a subset of ovarian cancer cell lines. Stimulation of G-CSFR-expressing ovarian epithelial cancer cells with G-CSF led to increased migration and survival, including against chemotherapy-induced apoptosis. The effects of G-CSF were mediated by signalling via the downstream JAK2/STAT3 pathway. This study suggests that G-CSF has the potential to impact on ovarian cancer pathogenesis, and that G-CSFR expression status should be considered in determining appropriate therapy.
登录
查看更多内容
影响因子：
11.4
作者：
Gits, J.;van Leeuwen, D.;Ward, A. C.
通讯作者：
Ward, A. C.
影响因子：
3.1
作者：
Kandala, Prabodh K.;Srivastava, Sanjay K.
通讯作者：
Srivastava, Sanjay K.
影响因子：
4.6
作者：
Hirai, K;Kumakiri, M;Fukuda, M
通讯作者：
Fukuda, M
影响因子：
1.5
作者：
Bookman, Michael A.
通讯作者：
Bookman, Michael A.
影响因子：
15.9
作者：
Gao, Sizhi Paul;Mark, Kevin G.;Bromberg, Jacqueline F.
通讯作者：
Bromberg, Jacqueline F.