Elucidation of a novel pathway through which HDAC1 controls cardiomyocyte differentiation through expression of SOX-17 and BMP2.
Elucidation of a novel pathway through which HDAC1 controls cardiomyocyte differentiation through expression of SOX-17 and BMP2.
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DOI：
10.1371/journal.pone.0045046
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kishore R
中科院分区：
文献类型：
--
作者：
Hoxha E;Lambers E;Wasserstrom JA;Mackie A;Ramirez V;Abramova T;Verma SK;Krishnamurthy P;Kishore R
胚胎干细胞不仅在再生医学中具有很大的潜力，而且在整个动物基因敲除实验失败的情况下，也为研究哺乳动物的特定发育过程和途径提供了一种优雅而有效的方法。我们通过控制胚胎干细胞分化早期SOX17和BMP2的表达，研究了HDAC1影响ES细胞心血管分化和心肌细胞分化的途径。这一数据解释了目前HDAC1在心血管分化中作用的差异，并揭示了ES细胞决定心血管细胞命运的新途径。
Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate.
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