Fibroblast Growth Factor 21: A Fascinating Perspective on the Regulation of Muscle Metabolism.
Fibroblast Growth Factor 21: A Fascinating Perspective on the Regulation of Muscle Metabolism.
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DOI：
10.3390/ijms242316951
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发表时间：
2023-11-29
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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成纤维细胞生长因子21 （Fibroblast growth factor 21, FGF21）在内源激素变化、外源刺激等内外因素的影响下，对真核生物的正常发育和稳态代谢起着至关重要的作用。在过去的几十年里，全面的研究揭示了FGF21在调节许多基本代谢途径中的关键作用，包括肌肉应激反应、胰岛素信号传导和肌肉发育。通过协调这些代谢途径，FGF21被认为有助于适应应激环境并随后恢复细胞和组织的稳态。本文以FGF21为重点，综述了FGF21的产生、调控及其在肌肉代谢中的作用的研究进展。我们还强调了FGF21代谢网络如何介导线粒体功能障碍、糖原消耗和肌原发育，并探讨了FGF21及其下游效应物（如哺乳动物雷帕霉素靶点（mTOR））功能开发的前景方向。
Fibroblast growth factor 21 (FGF21) plays a vital role in normal eukaryotic organism development and homeostatic metabolism under the influence of internal and external factors such as endogenous hormone changes and exogenous stimuli. Over the last few decades, comprehensive studies have revealed the key role of FGF21 in regulating many fundamental metabolic pathways, including the muscle stress response, insulin signaling transmission, and muscle development. By coordinating these metabolic pathways, FGF21 is thought to contribute to acclimating to a stressful environment and the subsequent recovery of cell and tissue homeostasis. With the emphasis on FGF21, we extensively reviewed the research findings on the production and regulation of FGF21 and its role in muscle metabolism. We also emphasize how the FGF21 metabolic networks mediate mitochondrial dysfunction, glycogen consumption, and myogenic development and investigate prospective directions for the functional exploitation of FGF21 and its downstream effectors, such as the mammalian target of rapamycin (mTOR).
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影响因子：
5.2
作者：
Luo Y;McKeehan WL
通讯作者：
McKeehan WL
影响因子：
8
作者：
Abdon, Benedict;Liang, Yusheng;Scheffer, Debora da Luz;Torres, Mauricio;Shrestha, Neha;Reinert, Rachel B.;Lu, You;Pederson, Brent;Bugarin-Lapuz, Amara;Kersten, Sander;Qi, Ling
通讯作者：
Qi, Ling
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5.2
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作者：
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通讯作者：
Varela-Rey, Marta
影响因子：
37.8
作者：
Damluji, Abdulla A.;Alfaraidhy, Maha;AlHajri, Noora;Rohant, Namit N.;Kumar, Manish;Al Malouf, Christina;Bahrainy, Samira;Kwak, Min Ji;Batchelor, Wayne B.;Forman, Daniel E.;Rich, Michael W.;Kirkpatrick, James;Krishnaswami, Ashok;Alexander, Karen P.;Gerstenblith, Gary;Cawthon, Peggy;deFilippi, Christopher R.;Goyal, Parag
通讯作者：
Goyal, Parag