Does being drunk or high cause HIV sexual risk behavior? A systematic review of drug administration studies.
Does being drunk or high cause HIV sexual risk behavior? A systematic review of drug administration studies.
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DOI：
10.1016/j.pbb.2017.08.009
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Johnson MW
中科院分区：
文献类型：
--
作者：
Berry MS;Johnson MW
艾滋病毒性危险行为与物质使用广泛相关。然而，关于物质使用（例如中毒）和艾滋病毒性危险行为之间的潜在因果关系仍然存在关键问题。本系统综述旨在检查和综合有关物质管理对艾滋病毒性危险行为影响的现有文献。其中包括调查药物管理和艾滋病毒性危险行为（例如，在随意性行为中使用安全套的可能性）的随机对照实验。在五个数据库中，审查了 2,750 个标题/摘要，总共有 43 份经过同行评审的已发表手稿合格（很少是多研究手稿，这些细节在文本中概述）。大多数文章研究了急性饮酒对艾滋病毒性危险行为的因果作用，尽管一篇文章研究了急性四氢大麻酚的影响，一篇研究了急性可卡因的影响，两篇研究了丁螺环酮的影响。本综述的结果表明，急性酒精中毒与增加艾滋病毒性风险决策之间存在因果关系。尽管其他物质的证据有限，但可卡因似乎也会增加性风险，而急性大麻和丁螺环酮维持可能会降低性风险。在酒精中毒的情况下，药理作用独立地影响艾滋病毒性风险决策，并且这些影响因酒精预期、性兴奋增加和避孕套使用延迟而加剧。各项研究的比较表明，可卡因比酒精更能导致自我报告的性唤起，这可能表明不同的风险状况。艾滋病毒预防措施应考虑这些药物管理的影响。增加向公众免费提供的安全套数量可能会减轻急性中毒对艾滋病毒性风险决策的影响。
HIV sexual risk behavior is broadly associated with substance use. Yet critical questions remain regarding the potential causal link between substance use (e.g., intoxication) and HIV sexual risk behavior. The present systematic review was designed to examine and synthesize the existing literature regarding the effects of substance administration on HIV sexual risk behavior. Randomized controlled experiments investigating substance administration and HIV sexual risk behavior (e.g., likelihood of condom use in a casual sex scenario) were included. Across five databases, 2,750 titles/abstracts were examined and forty-three total peer reviewed published manuscripts qualified (few were multi-study manuscripts, and those details are outlined in the text). The majority of articles investigated the causal role of acute alcohol administration on HIV sexual risk behavior, although one article investigated the effects of acute THC administration, one the effects of acute cocaine administration, and two the effects of buspirone. The results of this review suggest a causal role in acute alcohol intoxication increasing HIV sexual risk decision-making. Although evidence is limited with other substances, cocaine administration also appears to increase sexual risk, while acute cannabis and buspirone maintenance may decrease sexual risk. In the case of alcohol intoxication, the pharmacological effects independently contribute to HIV sexual risk decision-making, and these effects are exacerbated by alcohol expectancies, increased arousal, and delay to condom availability. Comparisons across studies showed that cocaine led to greater self-reported sexual arousal than alcohol, potentially suggesting a different risk profile. HIV prevention measures should take these substance administration effects into account. Increasing the amount of freely and easily accessible condoms to the public may attenuate the influence of acute intoxication on HIV sexual risk decision-making.
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影响因子：
4.4
作者：
Friedman SR;Mateu-Gelabert P;Ruggles KV;Goodbody E;Syckes C;Jessell L;Teubl J;Guarino H
通讯作者：
Guarino H
影响因子：
4.2
作者：
Davis, PE;Liddiard, H;McMillan, TM
通讯作者：
McMillan, TM
影响因子：
7.6
作者：
Bailey, Jennifer A.;Fleming, Charles B.;Haggerty, Kevin P.
通讯作者：
Haggerty, Kevin P.
影响因子：
4.4
作者：
Beckett, M;Burnam, A;Beckman, R
通讯作者：
Beckman, R
影响因子：
4.4
作者：
Davis, Kelly Cue;Masters, N. Tatiana;Heiman, Julia R.
通讯作者：
Heiman, Julia R.