Artificial synaptic modification reveals a dynamical invariant in the pyloric CPG.

Artificial synaptic modification reveals a dynamical invariant in the pyloric CPG.
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人工突触修饰揭示了幽门 CPG 的动力学不变量。

DOI:
10.1007/s00421-007-0635-0
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发表时间:
2008
影响因子:
3
通讯作者:
Selverston,AllenI
Selverston,AllenI
中科院分区:
医学3区
文献类型:
--
作者:
Reyes,MarceloB;Huerta,Ramón;Rabinovich,MikhailI;Selverston,AllenI

文献摘要

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相似文献

中枢模式发生器(CPGs)神经元的顺序放电通常被认为是组成神经元的固有细胞属性和突触属性之间相互作用的结果。由于实验的限制,通常很难单独处理这些特性中的每一个的作用。我们已经通过使用甲壳类口胃CPG和动态钳制技术来测量网络对单个重要突触的选择性修饰的反应。我们的结果表明,在相同的实验操作中,不同准备材料的收缩(LP)和扩张(PD)神经元之间的爆发周期和相位滞后显示出显著的差异。尽管有这种可变性,但在所有的准备工作中,突发周期的变化和相同神经元之间的相位延迟的变化之间的比率被紧密地保存下来,揭示了系统中的一个动力学不变量。尽管在周期和相位滞后测量中存在个体差异,但这种动态不变量仍被保留,这表明网络参数之间存在严格管制的约束。
The sequential firing of neurons in central pattern generators (CPGs) is generally thought to be a result of an interaction between intrinsic cellular and synaptic properties of the component neurons. Due to experimental limitations, it is usually difficult to address the role of each of these properties separately. We have done so by using the crustacean stomatogastric CPG and the dynamic clamp technique to measure how the network responds to the selective modification of an individual important synapse. Our results show that the burst periods and the phase lags between the constrictor (LP) and dilator (PD) neurons across preparations showed significant variability during equivalent experimental manipulations. Despite this variability, the ratio between the change in the burst period and the change in the phase lag between the same neurons was tightly preserved in all preparations, revealing a dynamical invariant in the system. This dynamical invariant was preserved despite the individual variability in the period and phase lag measurements, suggesting a tightly regulated constraint between the parameters of the network.
DOI: --
发表时间: 1980
影响因子: 4.4
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影响因子: --
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