Polysaccharide-protein conjugates: a new generation of vaccines.
Polysaccharide-protein conjugates: a new generation of vaccines.
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多糖-蛋白质结合物：新一代疫苗。
DOI：
10.1093/infdis/161.5.821
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
R. Schneerson
中科院分区：
文献类型：
--
作者：
J. Robbins;R. Schneerson
对科学和医学实践的贡献是建立在我们前辈的肩膀上的。对我们来说，麦克斯韦·芬兰博士的肩膀格外宽阔有力：除了作为医生和教师的技能之外，他还是一位有远见的科学家。芬兰博士的职业生涯始于对肺炎局部性肺炎患者的护理和研究[1,2]。他意识到有必要了解荚膜肺炎球菌多糖（CP）的免疫学特性及其与该病原体引起的临床疾病的关系。表1引用了他的一些贡献，这些贡献指导我们努力开发有效的疫苗，以预防由被封装的细菌病原体引起的全身感染[3-16]。我们的主要兴趣是预防乙型流感嗜血杆菌（Hib）引起的脑膜炎和其他全身性感染。我们和其他实验室在开发Hib结合物方面取得了迅速进展，三家公司生产的疫苗最近获得了18个月大儿童的许可。获准用于婴儿普遍免疫的Hib结合疫苗即将问世，与白喉、破伤风类毒素和百日咳疫苗（DTP）同时接种。我们相信，化学家和工程师将继续改进这些第一批Hib偶联物，甚至更有效的产品将很快问世。因此，除了回顾我们和我们的同事对这些新的Hib疫苗的贡献外，我们还将说明多糖蛋白偶联物的发展如何为研究其他细菌性疾病的发病机制提供机会，并最终通过新疫苗预防它们。表面多糖既可以作为毒力因子，也可以作为细菌的保护性抗原，这些细菌入侵血液是其主要致病事件。这些
Contributions to science and to the practice of medicine are built on the shoulders of our predecessors. For us, the shoulders of Dr. Maxwell Finland were singularly broad and strong: In addition to his skills as a physician and a teacher, he was a visionary and a scientist. Dr. Finland started his career by caring for and studying patients with pneumooccal pneumonia [1,2]. He realized the need for understanding the immunologic properties of the pneumococcus capsular polysaccharides (CP) and their relation to clinical disease caused by this pathogen. Some of his contributions that guided our efforts to develop effective vaccines for prevention of systemic infections due to capsulated bacterial pathogens are cited in table 1 [3-16]. Our main interest has been toward preventing meningitis and other systemic infections caused by Haemophilus influenzae type b (Hib). Progress by us and by other laboratories toward developing Hib conjugates has been rapid, and vaccines manufactured by three companies have been licensed recently for children ^18 months of age. The advent of Hib conjugates licensed for universal immunization of infants, administered concurrently with diphtheria and tetanus toxoids and pertussis vaccine (DTP), is imminent. We are confident that chemists and engineers will continue to improve these first Hib conjugates and that even more effective products will be available soon. Accordingly, in addition to reviewing our contributions and those of our colleagues with these new Hib vaccines, we will illustrate how the development of polysaccharide-protein conjugates may provide opportunities for studying the pathogenesis of other bacterial diseases and ultimately for preventing them through new vaccines. Surface polysaccharides may serve both as virulence factors and as protective antigens for bacteria whose invasion of the blood is their primary pathogenic event [17]. These
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接受多价肺炎球菌疫苗的镰状细胞性贫血儿童的类型特异性抗体。
DOI：
10.1016/s0022-3476(82)80440-x
发表时间：
1982
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Kaplan,J;Frost,H;Sarnaik,S;Schiffman,G
通讯作者：
Schiffman,G
两名对荚膜多糖疫苗无反应的 IgG2 缺乏症患者对乙型流感嗜血杆菌寡糖-蛋白结合疫苗的反应。
DOI：
10.1056/nejm198608213150807
发表时间：
1986
期刊：
The New England journal of medicine
影响因子：
--
作者：
Insel,RA;Anderson,PW
通讯作者：
Anderson,PW
III B 型链球菌荚膜多糖寡糖重复单元的结构和免疫化学。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wessels,MR;Pozsgay,V;Kasper,DL;Jennings,HJ
通讯作者：
Jennings,HJ
铜绿假单胞菌外毒素 A：酪氨酸 470 和酪氨酸 481 突变为苯丙氨酸的影响。
影响因子：
2.9
作者：
Lukac,M;Collier,RJ
通讯作者：
Collier,RJ