Oil phase evaporation-induced self-assembly of hydrophobic nanoparticles into spherical clusters with controlled surface chemistry in an oil-in-water dispersion and comparison of behaviors of individual and clustered iron oxide nanoparticles.
Oil phase evaporation-induced self-assembly of hydrophobic nanoparticles into spherical clusters with controlled surface chemistry in an oil-in-water dispersion and comparison of behaviors of individual and clustered iron oxide nanoparticles.
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DOI：
10.1021/ja102138a
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发表时间：
2010-12-22
影响因子：
15
通讯作者：
Mao, Chuanbin
中科院分区：
文献类型：
--
作者：
Qiu, Penghe;Jensen, Christina;Charity, Njoku;Towner, Rheal;Mao, Chuanbin
我们报道了一种在十六烷基三甲基溴化铵（CTAB）介导的水包油乳液体系中制备纳米粒子簇（NPCs）的通用方法，在此之前，该体系只能得到单个纳米粒子。我们已经制备了磁性、金属和半导体纳米粒子的纳米粒子簇，以证明该方法的通用性。纳米粒子簇呈球形，由紧密堆积的单个纳米粒子组成。发现油相中纳米粒子的数密度对纳米粒子簇的形成、形态和产率至关重要。这里开发的方法具有可扩展性，在水中浓度为5mg/ml时能以近100%的产率生产纳米粒子簇，这大约是文献报道的最高值的5倍。通过类似的过程，用含有不同官能团的聚合物替代CTAB，也可以控制纳米粒子簇的表面化学性质。纳米粒子簇可重复生产且形状明确，这使我们能够比较单个和聚集的氧化铁纳米粒子的性质，包括磁化强度、磁矩以及在磁共振成像（MRI）中的造影增强效果。我们发现，由于其集体性质，纳米粒子簇对外部磁场更敏感，在MRI中可能比单独分散的磁性纳米粒子更适合作为造影增强剂。
We report a general method for preparing nanoparticle clusters (NPCs) in an oil-in-water emulsion system mediated by cetyl trimethylammonium bromide (CTAB) where previously, only individual nanoparticles were obtained. NPCs of magnetic, metallic and semiconductor nanoparticles have been prepared to demonstrate the generality of the method. The NPCs were spherical and composed of densely packed individual nanoparticles. The number density of nanoparticles in the oil phase was found to be critical for the formation, morphology and yield of NPCs. The method developed here is scalable and can produce NPCs in nearly 100% yield at a concentration of 5 mg/ml in water which is approximately 5 times higher than the highest value reported in literature. The surface chemistry of NPCs can also be controlled by replacing CTAB with polymers containing different functional groups via a similar procedure. The reproducible production of NPCs with well defined shapes has allowed us to compare the properties of individual and clustered iron oxide nanoparticles including magnetization, magnetic moments and contrast enhancement in magnetic resonance imaging (MRI). We found that due to their collective properties, NPCs are more responsive to an external magnetic field and can potentially serve as better contrast enhancement agents than individually dispersed magnetic NPs in MRI.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
航空发动机转子-球轴承-支架-定子联轴器系统摩擦联轴器故障的非线性动力学分析与实验验证
DOI：
10.1115/1.2940355
发表时间：
2010-02-01
影响因子：
1.5
作者：
Chen, G.;Li, C. G.;Wang, D. Y.
通讯作者：
Wang, D. Y.
影响因子：
19
作者：
Fan, Hongyou;Wright, Adam;Jiang, Ying-Bing
通讯作者：
Jiang, Ying-Bing
影响因子：
16.6
作者：
Ge, Jianping;Hu, Yongxing;Yin, Yadong
通讯作者：
Yin, Yadong
影响因子：
4.9
作者：
Gullotti E;Yeo Y
通讯作者：
Yeo Y