Substrate utilization during submaximal exercise in children with a severely obese parent.
Substrate utilization during submaximal exercise in children with a severely obese parent.
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DOI：
10.1186/1743-7075-9-38
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发表时间：
2012-05-09
影响因子：
4.5
通讯作者：
Houmard JA
中科院分区：
文献类型：
--
作者：
Eaves AD;Colon A;Dubose KD;Collier D;Houmard JA
我们报道了严重肥胖（BMI≥40 kg/m2）个体在全身水平和骨骼肌中脂肪酸氧化（FAO）的减少；这种缺陷在细胞培养中保留，这表明存在固有的成分。本研究的目的是确定父母严重肥胖的儿童是否也明显存在全身脂肪酸氧化（FAO）损伤。在8-12岁的儿童中，如果父母有严重肥胖（OP, n = 13）或父母有两个瘦弱/非肥胖（BMI范围为18 - 28 kg/m2） （LP, n = 13），则对亚最大运动（循环测力计）期间的底物利用率进行测定。一组受试者（n = 3/组）进行了4周的运动训练，并在干预后测量底物利用率。儿童的年龄（LP vs OP分别为10.7±0.5 vs 10.2±0.5 y）， BMI百分比（65.3±5.2 vs 75.9±7），Tanner分期（1.4±0.2 vs 1.5±0.2），VO2peak（40.3±2.7 vs 35.6±2.6 ml/kg/min）或体力活动水平（加速度计）没有差异。在相同的绝对工作量为15 W （~38% vo2峰值）时，LP组的RER显著（P≤0.05）低于OP组（0.83±0.02比0.87±0.01），这反映了OP组对FAO能量生产的依赖减少（58.6±5.1比43.1±4.0%）。在更高的运动强度（~65%的vo2峰值）下，低脂和高脂动物对底物的利用没有差异。运动训练后，在15 W的工作量下，RER趋于下降（P = 0.06），这表明无论哪种动物对FAO的依赖都有所增加。这些发现表明，严重肥胖导致的FAO下降有其固有的因素，可以通过运动训练来克服。
We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an inherent component. The purpose of the current study was to determine if an impairment in whole-body fatty acid oxidation (FAO) was also evident in children with a severely obese parent. Substrate utilization during submaximal exercise (cycle ergometer) was determined in children ages 8–12 y with a severely obese parent (OP, n = 13) or two lean/non-obese (BMI range of 18 to 28 kg/m2) parents (LP, n = 13). A subgroup of subjects (n = 3/group) performed 4 weeks of exercise training with substrate utilization measured after the intervention. The children did not differ in age (LP vs. OP, respectively) (10.7 ± 0.5 vs. 10.2 ± 0.5 y), BMI percentile (65.3 ± 5.2 vs. 75.9 ± 7), Tanner Stage (1.4 ± 0.2 vs. 1.5 ± 0.2), VO2peak (40.3 ± 2.7 vs. 35.6 ± 2.6 ml/kg/min) or physical activity levels (accelerometer). At the same absolute workload of 15 W (~38% VO2peak), RER was significantly (P ≤ 0.05) lower in LP vs. OP (0.83 ± 0.02 vs. 0.87 ± 0.01) which was reflected in a reduced reliance on FAO for energy production in the OP group (58.6 ± 5.1 vs. 43.1 ± 4.0% of energy needs during exercise from FAO). At a higher exercise intensity (~65% VO2peak) there were no differences in substrate utilization between LP and OP. After exercise training RER tended to decrease (P = 0.06) at the 15 W workload, suggesting an increased reliance on FAO regardless of group. These findings suggest that the decrement in FAO with severe obesity has an inherent component that may be overcome with exercise training.
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影响因子：
2.9
作者：
Drenowatz, Clemens;Eisenmann, Joey C.;Walsh, David
通讯作者：
Walsh, David
DOI：
10.1038/sj.ijo.0802589
发表时间：
2004-02-01
期刊：
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Giacco, R;Clemente, G;Riccardi, G
通讯作者：
Riccardi, G
影响因子：
29
作者：
Hulver, MW;Berggren, JR;Muoio, DM
通讯作者：
Muoio, DM
影响因子：
1.8
作者：
Duncan, GE;Howley, ET
通讯作者：
Howley, ET
影响因子：
7.7
作者：
Consitt LA;Bell JA;Koves TR;Muoio DM;Hulver MW;Haynie KR;Dohm GL;Houmard JA
通讯作者：
Houmard JA