Global organization of a binding site network gives insight into evolution and structure-function relationships of proteins.
Global organization of a binding site network gives insight into evolution and structure-function relationships of proteins.
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DOI：
10.1038/s41598-017-10412-z
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发表时间：
2017-09-14
影响因子：
4.6
通讯作者：
Brooks BR
中科院分区：
文献类型：
--
作者：
Lee J;Konc J;Janežič D;Brooks BR
通过构建基于结构相似性的结合位点加权网络和基于最小描述长度原则检测结构相似结合位点的群落来分析蛋白质结合位点的全球组织。分析表明，存在两个中心结合位点社区，它们扮演较小外围社区的网络枢纽的角色。群落的大小服从幂函数分布，这表明较大的群落中包含的结合位点可能更古老，并一直是较新的结合位点的进化结构支架。同一群落中结构相似的结合位点混杂地与不同的配体结合，它们也嵌入不同的结构域结构中。了解结合位点相互作用的一般原理将为改进药物设计和蛋白质设计铺平道路。
The global organization of protein binding sites is analyzed by constructing a weighted network of binding sites based on their structural similarities and detecting communities of structurally similar binding sites based on the minimum description length principle. The analysis reveals that there are two central binding site communities that play the roles of the network hubs of smaller peripheral communities. The sizes of communities follow a power-law distribution, which indicates that the binding sites included in larger communities may be older and have been evolutionary structural scaffolds of more recent ones. Structurally similar binding sites in the same community bind to diverse ligands promiscuously and they are also embedded in diverse domain structures. Understanding the general principles of binding site interplay will pave the way for improved drug design and protein design.
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影响因子：
4.3
作者：
Gao M;Skolnick J
通讯作者：
Skolnick J
蛋白质结构域结构揭示了有氧代谢的起源和行星氧气的增加
影响因子：
5.7
作者：
Kim, Kyung Mo;Qin, Tao;Caetano-Anolles, Gustavo
通讯作者：
Caetano-Anolles, Gustavo
DOI：
10.1073/pnas.0606239103
发表时间：
2006-09-19
影响因子：
11.1
作者：
Choi, In-Geol;Kim, Sung-Hou
通讯作者：
Kim, Sung-Hou
影响因子：
14.9
作者：
Friedberg I;Godzik A
通讯作者：
Godzik A
影响因子：
56.9
作者：
Barabási, AL;Albert, R
通讯作者：
Albert, R