Exploring Barriers and Facilitators of Adherence to Artemisinin-Based Combination Therapies for the Treatment of Uncomplicated Malaria in Children in Freetown, Sierra Leone.
Exploring Barriers and Facilitators of Adherence to Artemisinin-Based Combination Therapies for the Treatment of Uncomplicated Malaria in Children in Freetown, Sierra Leone.
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DOI：
10.3390/healthcare9091233
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发表时间：
2021-09-18
期刊：
影响因子：
--
通讯作者：
Staedke SG
中科院分区：
文献类型：
--
作者：
Banek K;DiLiberto DD;Webb EL;Smith SJ;Chandramohan D;Staedke SG
坚持服药是疟疾治疗级联的一个重要步骤。我们在塞拉利昂弗里敦进行了一项定性研究，该研究嵌入了一项随机对照试验，比较了两种青蒿素联合疗法（ACT）治疗无并发症疟疾的推荐剂量的依从性。本研究探讨了影响照顾者坚持ACT规定为他们的孩子在试验中的情况和因素。与49名护理人员进行了深入访谈;所有访谈都进行了记录，转录和翻译。采用主题内容的方法，对成绩单进行了编码并按主题汇总。我们确定了影响最佳治疗依从性的四个关键因素：（1）卫生系统的影响，（2）卫生服务，（3）照顾者对疟疾疾病和治疗的经验，以及（4）药物特征。具体而言，护理人员报告说，他们对卫生系统有信心，因为设施维护良好，护理免费。他们还认为卫生工作者提供了高质量的护理，使他们信任卫生工作者并相信测试结果。给药的难易程度和副作用的感知风险，加上护理人员先前治疗疟疾的经验，影响了给药的方式。为确保青蒿素综合疗法取得最大效果，需要考虑这些背景因素，并进一步开发对儿童友好的抗疟药物。
Medication adherence is an essential step in the malaria treatment cascade. We conducted a qualitative study embedded within a randomized controlled trial comparing the adherence to the recommended dosing of two artemisinin-based combination therapies (ACT) to treat uncomplicated malaria in Freetown, Sierra Leone. This study explored the circumstances and factors that influenced caregiver adherence to the ACT prescribed for their child in the trial. In-depth interviews were conducted with 49 caregivers; all interviews were recorded, transcribed, and translated. Transcripts were coded and aggregated into themes, applying a thematic content approach. We identified four key factors that influenced optimal treatment adherence: (1) health system influences, (2) health services, (3) caregivers’ experiences with malaria illness and treatment, and (4) medication characteristics. Specifically, caregivers reported confidence in the health system as facilities were well maintained and care was free. They also felt that health workers provided quality care, leading them to trust the health workers and believe the test results. Ease of medication administration and perceived risk of side effects coupled with caregivers’ prior experience treating malaria influenced how medications were administered. To ensure ACTs achieve maximum effectiveness, consideration of these contextual factors and further development of child-friendly antimalarials are needed.
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影响因子：
5.4
作者：
Agyepong, IA;Ansah, E;Evans, D
通讯作者：
Evans, D
肯尼亚加里萨和布尼亚拉地区坚持以青蒿素为基础的联合疗法。
影响因子：
3
作者：
Lawford H;Zurovac D;O'Reilly L;Hoibak S;Cowley A;Munga S;Vulule J;Juma E;Snow RW;Allan R
通讯作者：
Allan R
影响因子：
11.8
作者：
Mace, Kimberly E.;Mwandama, Dyson;Skarbinski, Jacek
通讯作者：
Skarbinski, Jacek
马拉维奇克瓦瓦（Chikhwawa）区的幼儿的抗疟疾人的感知和利用是肉眼素和二氢氨基氨酸蛋白酶素：一项混合方法研究。
影响因子：
3
作者：
Ewing VL;Terlouw DJ;Kapinda A;Pace C;Richards E;Tolhurst R;Lalloo DG
通讯作者：
Lalloo DG
DOI：
10.1136/bmj.b2763
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Achan J;Tibenderana JK;Kyabayinze D;Wabwire Mangen F;Kamya MR;Dorsey G;D'Alessandro U;Rosenthal PJ;Talisuna AO
通讯作者：
Talisuna AO