Resistance training reduces disability in prostate cancer survivors on androgen deprivation therapy: evidence from a randomized controlled trial.
Resistance training reduces disability in prostate cancer survivors on androgen deprivation therapy: evidence from a randomized controlled trial.
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DOI：
10.1016/j.apmr.2014.08.010
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发表时间：
2015-01
影响因子：
4.3
通讯作者：
Beer, Tomasz M.
中科院分区：
文献类型：
--
作者：
Winters-Stone, Kerri M.;Dobek, Jessica C.;Bennett, Jill A.;Dieckmann, Nathan F.;Maddalozzo, Gianni F.;Ryan, Christopher W.;Beer, Tomasz M.
研究功能性抗阻运动是否可以改善雄激素剥夺治疗（ADT）的前列腺癌幸存者（PCS）的力量、身体功能和残疾;并探索运动结局变化的潜在介质。随机对照试验。学术医疗中心。接受ADT治疗的PCS（N=51;平均年龄，70.2岁）。PCS被随机分配到中等强度到剧烈强度的阻力训练或拉伸（安慰剂对照）1年。最大腿部推举和卧推力量、客观和自我报告的身体功能以及自我报告的残疾。使用分层线性模型检验显著的组×时间差异，调整协变量。研究中的保留率为84%，在抵抗组中，监督课程的平均出勤率为84%。未发生研究相关损伤。最大腿部力量（P= 0.032）和卧推力量（P= 0.027）在1年的阻力训练后得到改善，而拉伸几乎没有变化。自我报告的身体功能随着阻力训练而改善，而拉伸则下降（P=.016）。阻力训练比拉伸训练更能减轻残疾（P= 0.018）。腿部压力强度的一年变化介导了组间（阻力或拉伸）和自我报告残疾的一年变化之间的关系（P<0.05）。一年的阻力训练改善了雄激素剥夺PCS的肌肉力量。使用功能性运动模式加强肌肉可能是旨在改善身体功能和残疾感知的锻炼计划的重要特征。这项研究的结果有助于越来越多的证据表明，运动应该成为晚期前列腺癌老年男性临床护理的常规部分。
To investigate whether functionally based resistance exercise could improve strength, physical function, and disability among prostate cancer survivors (PCS) on androgen deprivation therapy (ADT); and to explore potential mediators of changes in outcomes from exercise. Randomized controlled trial. Academic medical center. PCS (N=51; mean age, 70.2y) on ADT. PCS were randomized to moderate to vigorous intensity resistance training or stretching (placebo control) for 1 year. Maximal leg press and bench press strength, objective and self-reported physical function, and self-reported disability. Hierarchical linear modeling was used to test for significant group × time differences adjusting for covariates. Retention in the study was 84%, and median attendance to supervised classes was 84% in the resistance group. No study-related injuries occurred. Maximal leg strength (P=.032) and bench press strength (P=.027) were improved after 1 year of resistance training, whereas little change occurred from stretching. Self-reported physical function improved with resistance training, whereas decreases occurred from stretching (P=.016). Disability lessened more with resistance training than stretching (P=.018). One-year change in leg press strength mediated the relation between groups (resistance or stretching) and 1-year change in self-reported disability (P<.05). One year of resistance training improved muscle strength in androgen-deprived PCS. Strengthening muscles using functional movement patterns may be an important feature of exercise programs designed to improve perceptions of physical function and disability. Findings from this study contribute to the mounting evidence that exercise should become a routine part of clinical care in older men with advanced prostate cancer.
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DOI：
10.1093/gerona/57.4.m209
发表时间：
2002-04-01
影响因子：
5.1
作者：
Jette, AM;Haley, SM;Ashba, J
通讯作者：
Ashba, J
影响因子：
1.5
作者：
Lane, Peter
通讯作者：
Lane, Peter
DOI：
10.1046/j.1532-5415.2001.49004.x
发表时间：
2001-01-01
影响因子：
6.3
作者：
Hauer, K;Rost, B;Schlierf, G
通讯作者：
Schlierf, G
影响因子：
3.7
作者：
Haseen, Farhana;Murray, Liam J.;Cantwell, Marie M.
通讯作者：
Cantwell, Marie M.
影响因子：
6.7
作者：
Campbell, AJ;Robertson, MC;Buchner, DM
通讯作者：
Buchner, DM