Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals.
Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals.
复制标题
乙酸细菌的合成生物学，可高效地将C1气体转化为生化物。
DOI：
10.3390/ijms21207639
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发表时间：
2020-10-15
影响因子：
5.6
通讯作者：
Cho BK
中科院分区：
文献类型：
--
作者：
Jin S;Bae J;Song Y;Pearcy N;Shin J;Kang S;Minton NP;Soucaille P;Cho BK
主要由化石燃料或生物质气化产生的合成气由C1气体如一氧化碳、二氧化碳和甲烷以及氢气组成。产乙酸菌（产乙酸菌）已成为一种替代解决方案，以回收C1气体，将它们转化为增值的生物化学品使用伍德-扬达尔途径。尽管利用产乙酸菌作为生物催化剂具有优势，但由于其生长速度慢且生产率低，因此难以开发工业规模的生物工艺。为了解决这些问题，已经应用了代谢工程的常规方法;然而，由于缺乏用于调节其代谢途径的所需遗传生物部件，存在若干限制。近年来，基于基因部分、模块和电路设计的合成生物学被积极开发，以克服产乙酸菌工程的局限性。本文综述了合成生物学在设计和构建产乙酸菌工业平台方面的应用。
Synthesis gas, which is mainly produced from fossil fuels or biomass gasification, consists of C1 gases such as carbon monoxide, carbon dioxide, and methane as well as hydrogen. Acetogenic bacteria (acetogens) have emerged as an alternative solution to recycle C1 gases by converting them into value-added biochemicals using the Wood-Ljungdahl pathway. Despite the advantage of utilizing acetogens as biocatalysts, it is difficult to develop industrial-scale bioprocesses because of their slow growth rates and low productivities. To solve these problems, conventional approaches to metabolic engineering have been applied; however, there are several limitations owing to the lack of required genetic bioparts for regulating their metabolic pathways. Recently, synthetic biology based on genetic parts, modules, and circuit design has been actively exploited to overcome the limitations in acetogen engineering. This review covers synthetic biology applications to design and build industrial platform acetogens.
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影响因子：
16.6
作者：
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通讯作者：
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