Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression.
Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression.
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DOI：
10.3390/antiox9100936
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发表时间：
2020-09-29
期刊：
影响因子：
--
通讯作者：
García-Giménez JL
中科院分区：
文献类型：
--
作者：
Beltrán-García J;Osca-Verdegal R;Pallardó FV;Ferreres J;Rodríguez M;Mulet S;Sanchis-Gomar F;Carbonell N;García-Giménez JL
自严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）爆发以来，全世界都在努力了解2019冠状病毒病（COVID-19）的分子机制，试图确定参与其发病机制的重症COVID-19患者的具体临床特征，并提供治疗方案，以尽量减少COVID-19的严重程度。最近，COVID-19与败血症密切相关，这表明重症监护室（ICU）中的大多数死亡可能是SARS-CoV-2感染引起的败血症的直接后果。了解导致COVID-19进展为严重表型（如脓毒症）的氧化应激和分子炎症机制是目前改善SARS-CoV-2感染患者治疗的临床需求。本文就SARS-CoV-2的分子发病机制及其与氧化应激和炎症的关系进行综述。我们还提供了潜在的抗氧化剂治疗和积极的临床试验，可能会阻止疾病进展或降低其严重程度的概述。
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak emerged, countless efforts are being made worldwide to understand the molecular mechanisms underlying the coronavirus disease 2019 (COVID-19) in an attempt to identify the specific clinical characteristics of critically ill COVID-19 patients involved in its pathogenesis and provide therapeutic alternatives to minimize COVID-19 severity. Recently, COVID-19 has been closely related to sepsis, which suggests that most deceases in intensive care units (ICU) may be a direct consequence of SARS-CoV-2 infection-induced sepsis. Understanding oxidative stress and the molecular inflammation mechanisms contributing to COVID-19 progression to severe phenotypes such as sepsis is a current clinical need in the effort to improve therapies in SARS-CoV-2 infected patients. This article aims to review the molecular pathogenesis of SARS-CoV-2 and its relationship with oxidative stress and inflammation, which can contribute to sepsis progression. We also provide an overview of potential antioxidant therapies and active clinical trials that might prevent disease progression or reduce its severity.
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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