N-Acetylcysteine and Atherosclerosis: Promises and Challenges.
N-Acetylcysteine and Atherosclerosis: Promises and Challenges.
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DOI：
10.3390/antiox12122073
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发表时间：
2023-12-04
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动脉粥样硬化仍然是心血管疾病的主要原因。尽管动脉粥样硬化的机制复杂且尚未完全了解，但炎症和氧化应激在动脉粥样硬化的发生发展中起着至关重要的作用。N-乙酰半胱氨酸(NAC)已被用作对乙酰氨基酚过量的粘液剂和解毒剂，具有良好的安全性。NAC通过多种机制具有抗氧化和抗炎作用，包括增加细胞内谷胱甘肽水平和减少核因子-kappa-B介导的炎性细胞因子的产生，如肿瘤坏死因子-α和白细胞介素2。大量动物研究表明，NAC可显著抑制动脉粥样硬化的发生和发展。然而，关于动脉粥样硬化患者的临床研究结果的数据一直是有限的和不一致的。本文就NAC抗动脉粥样硬化作用的临床前研究和临床研究资料进行综述，并探讨NAC抗动脉粥样硬化的可能机制以及该领域面临的挑战。
Atherosclerosis remains a leading cause of cardiovascular diseases. Although the mechanism for atherosclerosis is complex and has not been fully understood, inflammation and oxidative stress play a critical role in the development and progression of atherosclerosis. N-acetylcysteine (NAC) has been used as a mucolytic agent and an antidote for acetaminophen overdose with a well-established safety profile. NAC has antioxidant and anti-inflammatory effects through multiple mechanisms, including an increase in the intracellular glutathione level and an attenuation of the nuclear factor kappa-B mediated production of inflammatory cytokines like tumor necrosis factor-alpha and interleukins. Numerous animal studies have demonstrated that NAC significantly decreases the development and progression of atherosclerosis. However, the data on the outcomes of clinical studies in patients with atherosclerosis have been limited and inconsistent. The purpose of this review is to summarize the data on the effect of NAC on atherosclerosis from both pre-clinical and clinical studies and discuss the potential mechanisms of action of NAC on atherosclerosis, as well as challenges in the field.
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影响因子：
3.8
作者：
Calzadilla, P.;Gomez-Serrano, M.;Guerra, L. N.
通讯作者：
Guerra, L. N.
影响因子：
8
作者：
Cole SL;Dunning J;Kok WL;Benam KH;Benlahrech A;Repapi E;Martinez FO;Drumright L;Powell TJ;Bennett M;Elderfield R;Thomas C;MOSAIC investigators;Dong T;McCauley J;Liew FY;Taylor S;Zambon M;Barclay W;Cerundolo V;Openshaw PJ;McMichael AJ;Ho LP
通讯作者：
Ho LP
影响因子：
5
作者：
Cui, Yuqi;Liu, Lingjuan;Liu, Zhenguo
通讯作者：
Liu, Zhenguo
影响因子：
37.8
作者：
ARSTALL, MA;YANG, JF;HOROWITZ, JD
通讯作者：
HOROWITZ, JD
影响因子：
5.6
作者：
通讯作者：
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