Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide.
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide.
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DOI：
10.1016/j.cellimm.2012.03.010
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发表时间：
2012-03
影响因子：
4.3
通讯作者：
Cole, David J.
中科院分区：
文献类型：
--
作者：
Salem, Mohamed L.;Al-Khami, Amir A.;El-Nagaar, Sabry A.;Zidan, Abdel-Aziz A.;Al-Sharkawi, Ismail M.;Diaz-Montero, C. Marcela;Cole, David J.
关键词：
最近，我们发现环磷酰胺（CTX）后的微环境有利于转移的T细胞的功能。CTX处理后细胞恢复的动力学分析显示，单次4 mg/小鼠CTX处理在第3-15天降低了外周血（PBL）中白细胞的绝对数量，在第3-6天降低了脾和骨髓（BM）中白细胞的绝对数量。CD 11 c + CD 11 B −和CD 11 c + CD 11 B+树突状细胞（DC）、CD 11 B+和Ly 6 G+骨髓细胞、T和B细胞、CD 4 + CD 25 + T调节（Treg）细胞和NK 1.1+细胞的绝对数量也减少。在恢复期，细胞数量恢复至对照水平。B细胞的绝对数量在3周内保持较低水平。DC的数量在第9天增加，但在第15天恢复到对照水平。这些数据表明，CTX改变了细胞微环境的动力学，可能是精确的目标，以造福于主机。
Recently, we showed that post cyclophosphamide (CTX) microenvironment benefits the function of transferred T cells. Analysis of the kinetics of cellular recovery after CTX treatment showed that a single 4 mg/mouse CTX treatment decreased the absolute number of leukocytes in the peripheral blood (PBL) at days 3-15, and in the spleen and bone marrow (BM) at days 3-6. The absolute numbers of CD11c+CD11b− and CD11c+CD11b+ dendritic cells (DCs), CD11b+ and Ly6G+ myeloid cells, T and B cells, CD4+CD25+ T regulatory (Treg) cells, and NK1.1+ cells also decreased. The cell numbers returned to control levels during the recovery phase. The absolute numbers of B cells remained low for 3 weeks. The numbers of DCs increased in PBL and spleen at day 9 but returned to control levels at day 15. These data indicate that CTX alters the cellular microenvironment in kinetics that might be precisely targeted to benefit the host.
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通过淋巴结消除来清除稳态细胞因子下沉，增强了采用转移的肿瘤特异性CD8+ T细胞的功效。
影响因子：
15.3
作者：
Gattinoni, Luca;Finkelstein, Steven E;Klebanoff, Christopher A;Antony, Paul A;Palmer, Douglas C;Spiess, Paul J;Hwang, Leroy N;Yu, Zhiya;Wrzesinski, Claudia;Heimann, David M;Surh, Charles D;Rosenberg, Steven A;Restifo, Nicholas P
通讯作者：
Restifo, Nicholas P
影响因子：
5.6
作者：
Matar, P;Rozados, VR;Scharovsky, OG
通讯作者：
Scharovsky, OG
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
5.8
作者：
Matar, P;Rozados, VR;Scharovsky, OG
通讯作者：
Scharovsky, OG
影响因子：
5.4
作者：
Ghiringhelli, F;Larmonier, N;Martin, F
通讯作者：
Martin, F