The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.
The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.
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DOI：
10.3390/ijms23169029
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发表时间：
2022-08-12
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
复制依赖性组蛋白H3.1和复制非依赖性组蛋白H3.3在大多数多细胞真核生物中几乎是相同的蛋白质。这些H3变体的N-末端尾部（其中进行大部分组蛋白翻译后修饰）通常仅相差一个氨基酸。尽管与H3.3具有广泛的序列相似性，但H3.1变体被假设在细胞中发挥独特的作用，因为它在DNA复制期间特异性表达并插入染色质中。然而，在复制过程中识别H3.1特有的功能仍然是难以捉摸的。在这篇综述中，我们讨论了最近的研究结果，有关参与的H3.1变异在调节TSK/TONSL介导的决议停滞或中断的复制叉。通过鉴定第一个含有可以选择性结合或修饰H3.1变体的结构域的蛋白质，揭示H3.1变体的这种新功能成为可能。H3变体特异性阅读器和写入器的功能表征揭示了另一层基于染色质的信息调节转录、DNA复制和DNA修复。
Replication-dependent histone H3.1 and replication-independent histone H3.3 are nearly identical proteins in most multicellular eukaryotes. The N-terminal tails of these H3 variants, where the majority of histone post-translational modifications are made, typically differ by only one amino acid. Despite extensive sequence similarity with H3.3, the H3.1 variant has been hypothesized to play unique roles in cells, as it is specifically expressed and inserted into chromatin during DNA replication. However, identifying a function that is unique to H3.1 during replication has remained elusive. In this review, we discuss recent findings regarding the involvement of the H3.1 variant in regulating the TSK/TONSL-mediated resolution of stalled or broken replication forks. Uncovering this new function for the H3.1 variant has been made possible by the identification of the first proteins containing domains that can selectively bind or modify the H3.1 variant. The functional characterization of H3-variant-specific readers and writers reveals another layer of chromatin-based information regulating transcription, DNA replication, and DNA repair.
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影响因子：
10.5
作者：
Drane, Pascal;Ouararhni, Khalid;Hamiche, Ali
通讯作者：
Hamiche, Ali
影响因子：
64.5
作者：
Goldberg AD;Banaszynski LA;Noh KM;Lewis PW;Elsaesser SJ;Stadler S;Dewell S;Law M;Guo X;Li X;Wen D;Chapgier A;DeKelver RC;Miller JC;Lee YL;Boydston EA;Holmes MC;Gregory PD;Greally JM;Rafii S;Yang C;Scambler PJ;Garrick D;Gibbons RJ;Higgs DR;Cristea IM;Urnov FD;Zheng D;Allis CD
通讯作者：
Allis CD
DOI：
10.1016/bs.enz.2016.03.003
发表时间：
2016
期刊：
The Enzymes
影响因子：
--
作者：
Boehm EM;Gildenberg MS;Washington MT
通讯作者：
Washington MT
影响因子：
16
作者：
Abbas T;Shibata E;Park J;Jha S;Karnani N;Dutta A
通讯作者：
Dutta A
影响因子：
9.2
作者：
Fang, J;Feng, Q;Zhang, Y
通讯作者：
Zhang, Y