Numerical Simulation on Behaviour of Magnetic Beads in Magnetic Filter for Medical Protein Screening System using High Gradient Magnetic Separation
Numerical Simulation on Behaviour of Magnetic Beads in Magnetic Filter for Medical Protein Screening System using High Gradient Magnetic Separation
复制标题
高梯度磁分离医用蛋白筛选系统磁过滤器中磁珠行为的数值模拟
DOI：
10.1088/1742-6596/1054/1/012085
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
S B Kim and H Ueda
中科院分区：
文献类型：
--
作者：
M Kubota;Y Mori;S B Kim and H Ueda
近年来，抗体类药物引起了医学界的广泛关注。利用免疫功能的抗体疗效高，副作用相对较少，有望成为未来医学的主流。医用蛋白的连续、大量、高速分离是抗体药物开发不可缺少的技术。为此，我们提出了医用蛋白超导高梯度磁分离（HGMS）系统。利用超导磁体实现HGMS系统，可大大缩短分离处理时间。在之前的研究中，可以分离悬浮在纯水中的200 nm磁珠，结果捕获率为97.8%，收集率为94.1%。然而，根据悬浮液的类型，磁性过滤器的堵塞和磁性纳米珠未被捕获的现象已经得到证实。因此，在本研究中，考虑磁性过滤器中磁珠的二维行为，通过电磁流体和粒子示踪分析来评估磁性过滤器的磁力。
Recently, Antibody drugs are attracting attention in the medical field. Antibody using immune function has high efficacy and side effects are relatively few, so it is expected to become the mainstream of future medicine. Indispensable technologies for development of antibody drugs are continuous, large amount and high-speed separation of medical protein. Therefore, we have proposed superconducting high gradient magnetic separation (HGMS) system for medical protein. If HGMS system using superconducting magnet is realized, processing time of separation can be greatly shortened. In the previous studies, it was possible to separate 200 nm magnetic beads suspended in pure water, with the result that the capture ratio was 97.8% and the collection ratio was 94.1%. However, depending on the type of the suspension, the clogging of the magnetic filter and the phenomenon that the magnetic nano-beads are not trapped have been confirmed. Therefore, in this study, the magnetic force of the magnetic filter is evaluated by electromagnetic fluid and particle tracing analysis considering the behaviour of the magnetic beads two-dimensionally in the magnetic filter.
开发用于高梯度磁分离的磁过滤器消磁系统以提高捕获的磁纳米珠的回收率
影响因子：
1.8
作者：
K. Kajikawa;H. Ueda;Y. Kamioka;K. Agatsuma;S. Fuchino;M. Furuse;T. Iitsuka;Shuichi Nakamura
通讯作者：
Shuichi Nakamura