Integrity of medial temporal structures may predict better improvement of spatial neglect with prism adaptation treatment.
Integrity of medial temporal structures may predict better improvement of spatial neglect with prism adaptation treatment.
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DOI：
10.1007/s11682-012-9200-5
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发表时间：
2014-09
影响因子：
3.2
通讯作者：
Barrett, A. M.
中科院分区：
文献类型：
--
作者：
Chen, Peii;Goedert, Kelly M.;Shah, Priyanka;Foundas, Anne L.;Barrett, A. M.
关键词：
棱镜适应治疗（PAT）是一种很有前途的空间忽视患者功能恢复的康复方法。先前的研究表明，PAT改善了经常发生在额叶损伤中的运动故意“瞄准”缺陷。为了检验额叶损伤是否预示PAT后空间忽视的改善更好，本研究评估了21例右侧脑损伤卒中幸存者左侧空间忽视随时间推移的功能活动（使用Catherine Bergego量表评估）的忽视特异性改善。结果表明，忽视患者的功能活动在PAT两周后有所改善，并持续改善四周。这种功能改善并不是在所有参与者中平等发生的：额叶皮质病变的神经元病患者（n=13）比没有额叶病变的患者（n=8）经历了更好的功能改善。更重要的是，基于体素的病变行为映射（VLBM）显示，与无额叶病变的患者组相比，额叶病变性忽视患者的内侧颞区、上级颞区和下纵束区域完整。颞叶内侧皮质区和皮质下区在“额叶损伤”组中尤为明显。研究结果表明，内侧颞叶结构的完整性可能在支持PAT后的功能改善中发挥重要作用。
Prism adaptation treatment (PAT) is a promising rehabilitative method for functional recovery in persons with spatial neglect. Previous research suggests that PAT improves motor-intentional “aiming” deficits that frequently occur with frontal lesions. To test whether presence of frontal lesions predicted better improvement of spatial neglect after PAT, the current study evaluated neglect-specific improvement in functional activities (assessment with the Catherine Bergego Scale) over time in 21 right-brain-damaged stroke survivors with left-sided spatial neglect. The results demonstrated that neglect patients' functional activities improved after two weeks of PAT and continued improving for four weeks. Such functional improvement did not occur equally in all of the participants: Neglect patients with lesions involving the frontal cortex (n=13) experienced significantly better functional improvement than did those without frontal lesions (n=8). More importantly, voxel-based lesion-behavior mapping (VLBM) revealed that in comparison to the group of patients without frontal lesions, the frontal-lesioned neglect patients had intact regions in the medial temporal areas, the superior temporal areas, and the inferior longitudinal fasciculus. The medial cortical and subcortical areas in the temporal lobe were especially distinguished in the “frontal lesion” group. The findings suggest that the integrity of medial temporal structures may play an important role in supporting functional improvement after PAT.
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影响因子：
2.6
作者：
Angeli, V;Benassi, MG;Làdavas, E
通讯作者：
Làdavas, E
DOI：
10.1016/s0010-9452(08)70931-6
发表时间：
2004-02-01
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Angeli, Valentina;Meneghello, Francesca;Ladavas, Elisabetta
通讯作者：
Ladavas, Elisabetta
影响因子：
3.5
作者：
Appelros, P.
通讯作者：
Appelros, P.
影响因子：
2.6
作者：
Farnè, A;Rossetti, Y;Làdavas, E
通讯作者：
Làdavas, E
影响因子：
11
作者：
Azouvi, P;Samuel, C;Rousseaux, M
通讯作者：
Rousseaux, M