Fetal cyclic motor activity in diabetic pregnancies: sensitivity to maternal blood glucose.
Fetal cyclic motor activity in diabetic pregnancies: sensitivity to maternal blood glucose.
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糖尿病妊娠中胎儿的周期性运动活动：对母体血糖的敏感性。
DOI：
10.1002/dev.10045
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Dierker,LeRoyJ
中科院分区：
文献类型：
--
作者：
Robertson,StevenS;Dierker,LeRoyJ
人类妊娠最后三分之一的自发胎动主要是分钟级的不规则振荡（循环运动，CM）。这些振荡的核心特性在正常胎儿的妊娠晚期是稳定的，但会因母亲糖尿病控制不佳而受到干扰。在这里，我们研究了胎儿 CM 是否与母体葡萄糖代谢的短期不稳定有关。对 40 名患有 I 型 (n=≥28) 或妊娠期 (n=≥12) 糖尿病的母亲的胎儿在妊娠 27 至 40 周期间进行了 1 至 6 次研究。在每个疗程的两个单独的胎儿活动期间测量胎儿运动和母亲血糖浓度。通过光谱分析对胎儿 CM 进行量化。在妊娠晚期，两个活动期之间胎儿 CM 振荡率的变化与母体血糖水平的变化呈负相关。在妊娠晚期的任何时间点，胎儿 CM 与同时发生的母体血糖水平无关。结果模式表明，妊娠期并发母亲糖尿病时胎儿自发运动活动时间组织的破坏代表了对代谢环境波动的急性反应，而不是 CM 发育的改变。 © 2003 Wiley periodicals, Inc. Dev Psychobiol 42: 9–16, 2003。
Spontaneous fetal movement in the last third of human gestation is dominated by irregular oscillations on a scale of minutes (cyclic motility, CM). The core properties of these oscillations are stable during the third trimester of gestation in normal fetuses, but disrupted by poorly controlled maternal diabetes. Here we investigated whether fetal CM is linked to short‐term instabilities in maternal glucose metabolism. The fetuses of 40 mothers with type I (n= 28) or gestational (n= 12) diabetes were studied one to six times between 27 and 40 postmenstrual weeks of gestation. Fetal movement and maternal blood glucose concentration were measured during two separate periods of fetal activity in each session. Fetal CM was quantified with spectral analysis. Early in the third trimester, changes in the rate of oscillation in fetal CM between the two periods of activity were inversely related to changes in maternal blood glucose levels. Fetal CM was unrelated to concurrent maternal blood glucose levels at any point in the third trimester. The pattern of results suggests that disruption of the temporal organization of spontaneous fetal motor activity in pregnancies complicated by maternal diabetes represents an acute response to fluctuations in the metabolic environment rather than an alteration of CM development. © 2003 Wiley Periodicals, Inc. Dev Psychobiol 42: 9–16, 2003.
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