Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.
Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.
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DOI：
10.1053/j.gastro.2018.04.014
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发表时间：
2018-08
期刊：
影响因子：
29.4
通讯作者：
Loomba R
中科院分区：
文献类型：
--
作者：
Ajmera V;Park CC;Caussy C;Singh S;Hernandez C;Bettencourt R;Hooker J;Sy E;Behling C;Xu R;Middleton MS;Valasek MA;Faulkner C;Rizo E;Richards L;Sirlin CB;Loomba R
需要标志物来预测非酒精性脂肪性肝病（NAFLD）的进展。质子密度脂肪分数，通过磁共振成像（MRI-PDFF）测量，提供了一个准确的，有效的肝脏脂肪变性标志物。然而，目前尚不清楚质子密度脂肪分数是否能识别有NAFLD进展风险的患者。我们对95例活检证实的NAFLD患者进行了随访研究，并检查了肝脏脂肪含量与纤维化进展之间的关系。在研究开始时（基线）进行MRI-PDFF测量。分别在基线和平均1.75年后对患者进行活检。在基线无纤维化的患者中，高肝脂组（MRI-PDFF≥15.7%）中纤维化进展的患者比例（38.1%）高于低肝脂组（11.8%）（P= 0.067）。在多变量校正logistic回归模型中（根据年龄、性别、种族和体重指数进行校正），高肝脂组的患者发生纤维化进展的风险明显更高（多变量校正优势比为6.7；95% CI为1.01-44.1）（P= 0.049）。我们的研究结果表明，MRI-PDFF测量的肝脂肪含量较高与纤维化进展有关。
Markers are needed to predict progression of nonalcoholic fatty liver disease (NAFLD). The proton density fat fraction, measured by magnetic resonance imaging (MRI-PDFF), provides an accurate, validated marker of hepatic steatosis. However, it is not clear whether the proton density fat fraction identifies patients at risk for NAFLD progression. We performed a follow-up study of 95 well-characterized patients with biopsy-proven NAFLD and examined the association between liver fat content and fibrosis progression. MRI-PDFF measurements were made at study entry (baseline). Biopsies were collected from patients at baseline and after a mean time period of 1.75 years. Among patients with no fibrosis at baseline, a higher proportion of patients in the higher liver fat group (MRI-PDFF ≥ 15.7%) had fibrosis progression (38.1%) than in the lower liver fat group (11.8%) (P=.067). In multivariable-adjusted logistic regression models (adjusted for age, sex, ethnicity, and body mass index), patients in the higher liver fat group had a significantly higher risk of fibrosis progression (multivariable adjusted odds ratio, 6.7; 95% CI, 1.01–44.1) (P=.049). Our findings associate higher liver fat content, measured by MRI-PDFF, with fibrosis progression.
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影响因子：
7.6
作者：
Permutt Z;Le TA;Peterson MR;Seki E;Brenner DA;Sirlin C;Loomba R
通讯作者：
Loomba R
影响因子：
13.5
作者：
Rotman, Yaron;Koh, Christopher;Zmuda, Joseph M.;Kleiner, David E.;Liang, T. Jake
通讯作者：
Liang, T. Jake
影响因子：
4.4
作者：
Hines, Catherine D. G.;Frydrychowicz, Alex;Hamilton, Gavin;Tudorascu, Dana L.;Vigen, Karl K.;Yu, Huanzhou;McKenzie, Charles A.;Sirlin, Claude B.;Brittain, Jean H.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
29.4
作者：
Angulo P;Kleiner DE;Dam-Larsen S;Adams LA;Bjornsson ES;Charatcharoenwitthaya P;Mills PR;Keach JC;Lafferty HD;Stahler A;Haflidadottir S;Bendtsen F
通讯作者：
Bendtsen F
影响因子：
19.7
作者：
Tang, An;Desai, Ajinkya;Sirlin, Claude B.
通讯作者：
Sirlin, Claude B.