Advances in use of mouse models to study the renin-angiotensin system.
Advances in use of mouse models to study the renin-angiotensin system.
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DOI：
10.1016/j.mce.2021.111255
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发表时间：
2021-06-01
影响因子：
4.1
通讯作者：
Gurley, Susan B.
中科院分区：
文献类型：
--
作者：
Emathinger, Jacqueline M.;Nelson, Jonathan W.;Gurley, Susan B.
肾素-血管紧张素系统（RAS）是一个高度复杂的激素级联反应，跨越多个器官和细胞类型，调节溶质和液体平衡沿着心血管功能。我们目前对RAS功能的理解大部分来自一系列转基因动物的关键研究。在这里，我们回顾了突破性的转基因模型的关键发现，跨越了几十年的RAS研究，重点是它们在研究血压中的应用。我们审查的生理重要性，这一监管系统，通过检查几个主要的RAS组件的小鼠模型：血管紧张素原，肾素，ACE，ACE 2，和1A型血管紧张素受体。全动物和细胞特异性敲除模型都允许定义关键的RAS功能，并证明RAS内的冗余和多样性如何允许代偿性调节以维持稳态。此外，这些模型为围绕RAS在疾病发病机制和心血管疾病及其他疾病治疗中的作用的持续发现提供了令人兴奋的机会。
The renin-angiotensin system (RAS) is a highly complex hormonal cascade that spans multiple organs and cell types to regulate solute and fluid balance along with cardiovascular function. Much of our current understanding of the functions of the RAS has emerged from a series of key studies in genetically-modified animals. Here, we review key findings from ground-breaking transgenic models, spanning decades of research into the RAS, with a focus on their use in studying blood pressure. We review the physiological importance of this regulatory system as evident through the examination of mouse models for several major RAS components: angiotensinogen, renin, ACE, ACE2, and the type 1A angiotensin receptor. Both whole-animal and cell-specific knockout models have permitted critical RAS functions to be defined and demonstrate how redundancy and multiplicity within the RAS allow for compensatory adjustments to maintain homeostasis. Moreover, these models present exciting opportunities for continued discovery surrounding the role of the RAS in disease pathogenesis and treatment for cardiovascular disease and beyond.
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影响因子：
15.9
作者：
Gonzalez-Villalobos, Romer A.;Janjoulia, Tea;McDonough, Alicia A.
通讯作者：
McDonough, Alicia A.
影响因子：
64.8
作者：
Crackower, MA;Sarao, R;Penninger, JM
通讯作者：
Penninger, JM
影响因子：
13.6
作者：
Eriguchi, Masahiro;Bernstein, Ellen A.;Giani, Jorge F.
通讯作者：
Giani, Jorge F.
影响因子：
4.8
作者：
Gembardt, Florian;Heringer-Walther, Silvia;Walther, Thomas
通讯作者：
Walther, Thomas
DOI：
10.1016/s1357-2725(02)00309-6
发表时间：
2003-06-01
影响因子：
4
作者：
Coates, D
通讯作者：
Coates, D