Chromatin modifications in metabolic disease: Potential mediators of long-term disease risk.
Chromatin modifications in metabolic disease: Potential mediators of long-term disease risk.
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DOI：
10.1002/wsbm.1416
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Schones DE
中科院分区：
文献类型：
--
作者：
Costello KR;Schones DE
肥胖和糖尿病等代谢性疾病是由多种遗传和环境因素（如饮食和活动水平）引起的复杂疾病。众所周知，这些因素会导致代谢性疾病的发生。环境因素影响代谢性疾病进展的一种方式是通过染色质的修饰。这些修饰会导致基因调控程序的改变，从而改变疾病风险。此外，有证据表明，父母暴露于环境因素会影响后代的代谢健康，特别是在宫内生长期间。在这篇综述中，我们概述了染色质修饰与代谢疾病相关的证据，包括糖尿病和肥胖。我们还考虑了这些染色质修饰可能导致长期疾病风险并对后代造成疾病风险的证据。生物学机制>代谢发育生物学>健康与疾病生理学发育过程>机体对环境的反应本文分类如下：
Metabolic diseases such as obesity and diabetes are complex diseases resulting from multiple genetic and environmental factors, such as diet and activity levels. These factors are well known contributors to the development of metabolic diseases. One manner by which environmental factors can influence metabolic disease progression is through modifications to chromatin. These modifications can lead to altered gene regulatory programs, which alters disease risk. Furthermore, there is evidence that parents exposed to environmental factors can influence the metabolic health of offspring, especially if exposures are during intrauterine growth periods. In this review, we outline the evidence that chromatin modifications are associated with metabolic diseases, including diabetes and obesity. We also consider evidence that these chromatin modifications can lead to long‐term disease risk and contribute to disease risk for future generations. Biological Mechanisms > Metabolism Developmental Biology > Developmental Processes in Health and Disease Physiology > Organismal Responses to Environment This article is categorized under:
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