Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome.
Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome.
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DOI：
10.3390/nu12103136
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发表时间：
2020-10-14
期刊：
影响因子：
5.9
通讯作者：
Berry-Kravis EM
中科院分区：
文献类型：
--
作者：
Westmark CJ;Kniss C;Sampene E;Wang A;Milunovich A;Elver K;Hessl D;Talboy A;Picker J;Haas-Givler B;Esler A;Gropman AL;Uy R;Erickson C;Velinov M;Tartaglia N;Berry-Kravis EM
大量成人和儿童以各种形式食用大豆，但关于潜在的神经副作用的信息很少。先前的研究表明，在神经系统疾病的小鼠模型和自闭症儿童中，大豆饮食的消费与癫痫发作的患病率之间存在关联。在此，我们试图通过对脆性X在线注册与可扩展研究数据库（FORWARD）中登记的FXS参与者进行回顾性病例对照调查研究，评估婴儿期食用大豆配方奶粉与脆性X综合征（FXS）患者的疾病合并症之间的潜在关联，同时控制潜在的混淆问题。在研究人群中，大豆基婴儿配方奶粉的使用率为25%。我们发现，食用大豆基婴儿配方奶粉与自闭症、胃肠道问题（GI）和过敏症的合并症之间存在显著关联。具体来说，在报告使用大豆基婴儿配方奶粉的参与者中，自闭症的患病率高出1.5倍，GI问题高出1.9倍，过敏高出1.7倍。开始生产大豆基婴儿配方奶粉的主要原因是GI问题。癫痫发作和过敏发作的平均年龄发生在使用大豆基婴儿配方奶粉很长时间之后。我们的结论是，早期生活喂养大豆为基础的婴儿配方奶粉与发展的几种疾病合并症FXS。
A large number of adults and children consume soy in various forms, but little information is available regarding potential neurological side effects. Prior work indicates an association between the consumption of soy-based diets and seizure prevalence in mouse models of neurological disease and in children with autism. Herein, we sought to evaluate potential associations between the consumption of soy-based formula during infancy and disease comorbidities in persons with fragile X syndrome (FXS), while controlling for potentially confounding issues, through a retrospective case-control survey study of participants with FXS enrolled in the Fragile X Online Registry with Accessible Research Database (FORWARD). There was a 25% usage rate of soy-based infant formula in the study population. We found significant associations between the consumption of soy-based infant formula and the comorbidity of autism, gastrointestinal problems (GI) and allergies. Specifically, there was a 1.5-fold higher prevalence of autism, 1.9-fold GI problems and 1.7-fold allergies in participants reporting the use of soy-based infant formula. The major reason for starting soy-based infant formula was GI problems. The average age of seizure and allergy onset occurred long after the use of soy-based infant formula. We conclude that early-life feeding with soy-based infant formula is associated with the development of several disease comorbidities in FXS.
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影响因子：
8
作者：
Sherman SL;Kidd SA;Riley C;Berry-Kravis E;Andrews HF;Miller RM;Lincoln S;Swanson M;Kaufmann WE;Brown WT
通讯作者：
Brown WT
影响因子：
10.4
作者：
Harlid S;Adgent M;Jefferson WN;Panduri V;Umbach DM;Xu Z;Stallings VA;Williams CJ;Rogan WJ;Taylor JA
通讯作者：
Taylor JA
影响因子：
81.5
作者：
Hagerman, Randi J.;Berry-Kravis, Elizabeth;Hagerman, Paul J.
通讯作者：
Hagerman, Paul J.
影响因子：
4
作者：
Westmark, Cara J.;Westmark, Pamela R.;Malter, James S.
通讯作者：
Malter, James S.
影响因子：
1.5
作者：
Li, Juan;Dykman, Roscoe A.;Pivik, R. T.
通讯作者：
Pivik, R. T.