A Comparison of Pseudorabies Virus Latency to Other α-Herpesvirinae Subfamily Members.
A Comparison of Pseudorabies Virus Latency to Other α-Herpesvirinae Subfamily Members.
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伪狂犬病病毒潜伏期与其他 A-疱疹病毒亚科成员的比较
DOI：
10.3390/v14071386
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发表时间：
2022-06-24
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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伪狂犬病病毒（PRV）是奥耶斯基氏病的病原体，是威胁全球养猪业的最重要的传染性病原体之一。与α疱疹病毒的其他成员一样，PRV会建立终身潜伏感染，并且在感染猪受到应激刺激后偶尔会从潜伏状态重新激活。潜伏感染的猪可成为再次感染的源头，这是根除PRV的困难之一。病毒潜伏是指病毒完整基因组的保留而不产生有传染性的子代病毒；然而，在应激刺激后，病毒可重新激活为裂解性感染，这被称为潜伏 - 再激活循环。最近，一些研究表明，α疱疹病毒的潜伏和再激活是由病毒、神经元和免疫系统之间复杂的相互作用所调控。然而，由于相关报道有限，PRV潜伏方面的相关进展较为滞后。因此，在本综述中，我们通过总结PRV自身以及其他α疱疹病毒的研究进展，重点关注PRV潜伏的调控机制，这将增进我们对PRV潜伏潜在机制的理解，并有助于设计新的治疗策略来控制PRV潜伏。
Pseudorabies virus (PRV), the causative agent of Aujeszky’s disease, is one of the most important infectious pathogens threatening the global pig industry. Like other members of alphaherpesviruses, PRV establishes a lifelong latent infection and occasionally reactivates from latency after stress stimulus in infected pigs. Latent infected pigs can then serve as the source of recurrent infection, which is one of the difficulties for PRV eradication. Virus latency refers to the retention of viral complete genomes without production of infectious progeny virus; however, following stress stimulus, the virus can be reactivated into lytic infection, which is known as the latency-reactivation cycle. Recently, several research have indicated that alphaherpesvirus latency and reactivation is regulated by a complex interplay between virus, neurons, and the immune system. However, with those limited reports, the relevant advances in PRV latency are lagging behind. Therefore, in this review we focus on the regulatory mechanisms in PRV latency via summarizing the progress of PRV itself and that of other alphaherpesviruses, which will improve our understanding in the underlying mechanism of PRV latency and help design novel therapeutic strategies to control PRV latency.
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影响因子：
1.5
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