Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients.
Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients.
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自身抗体影响非神经精神系统性红斑狼疮患者的脑密度降低。
DOI：
10.1155/2015/920718
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发表时间：
2015
影响因子：
4.1
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Xu J;Cheng Y;Lai A;Lv Z;Campbell RA;Yu H;Luo C;Shan B;Xu L;Xu X
This study explores the relationship between autoantibodies and brain density reduction in SLE patients without major neuropsychiatric manifestation (NPSLE). Ninety-five NPSLE patients without obvious cerebral deficits, as determined by conventional MRI, as well as 89 control subjects, underwent high-resolution structural MRI. Whole-brain density of grey matter (GMD) and white matter (WMD) were calculated for each individual, and correlations between the brain density, symptom severity, immunosuppressive agent (ISA), and autoantibody levels were assessed. The GMD and WMD of the SLE group decreased compared to controls. GMD was negatively associated with SLE activity. The WMD of patients who received ISA treatment were higher than that in the patients who did not. The WMD of patients with anticardiolipin (ACL) or anti-SSB/La antibodies was lower than in patients without these antibodies, while the GMD was lower in patients with anti-SM or anti-U1RNP antibodies. Thus, obvious brain atrophy can occur very early even before the development of significant symptoms and specific autoantibodies might contribute to the reduction of GMD or WMD in NPSLE patients. However, ISAs showed protective effects in minimizing GMD and WMD reduction. The presence of these specific autoantibodies might help identify early brain damage in NPSLE patients.
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影响因子：
2.6
作者：
Abbott, NJ;Mendonça, LLF;Dolman, DEM
通讯作者：
Dolman, DEM
影响因子：
--
作者：
Chinn, RJS;Wilkinson, ID;Harrison, MJG
通讯作者：
Harrison, MJG
影响因子：
11.2
作者：
Appenzeller, Simone;Faria, Andrea Vasconcelos;Cendes, Fernando
通讯作者：
Cendes, Fernando
影响因子：
--
作者：
BOMBARDIER, C;GLADMAN, DD;CHANG, CH
通讯作者：
CHANG, CH
影响因子：
8.3
作者：
Sabet, A;Sibbitt, WL;Brooks, WM
通讯作者：
Brooks, WM