Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissions.
Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissions.
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DOI：
10.1289/ehp.1307081
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发表时间：
2014-07
影响因子：
10.4
通讯作者：
Heinz Nixdorf Recall Study Investigative Group
中科院分区：
文献类型：
--
作者：
Hennig F;Fuks K;Moebus S;Weinmayr G;Memmesheimer M;Jakobs H;Bröcker-Preuss M;Führer-Sakel D;Möhlenkamp S;Erbel R;Jöckel KH;Hoffmann B;Heinz Nixdorf Recall Study Investigative Group
背景资料：长期暴露于颗粒物空气污染（PM2.5和PM10）和高交通负荷与全身性炎症的标志物有关。流行病学调查主要集中在总PM上，它代表了来自不同来源的污染物的混合物。目的：我们研究了来源特异性PM和高敏C反应蛋白（hs-CRP）之间的关系，高敏C反应蛋白是心血管疾病的独立预测因子。研究方法：我们使用了海因茨Nixdorf召回研究的第一次（2000-2003）和第二次（2006-2008）检查的数据，该研究是一项前瞻性的基于人群的德国队列研究，最初有4,814名参与者（45-75岁）。我们使用化学运输模型估计了参与者住宅长期暴露于当地交通和行业特定细颗粒物（PM2.5）的情况。我们使用了一个线性混合模型与随机参与者截距来估计来源特异性PM和自然对数转换的hs-CRP之间的关联，控制年龄，性别，教育，体重指数，低密度和高密度脂蛋白胆固醇，吸烟变量，体力活动，季节，湿度和城市（共8，204个观察结果）。结果：PM2.5浓度每增加1 μg/m3，hs-CRP浓度增加4.53%（95%CI：2.76，6.33%）。hs-CRP分别升高17.89%（95% CI：7.66，29.09%）和7.96%（95% CI：3.45，12.67%），与交通和行业特定PM2.5增加1 μg/m3相关。PM10的结果相似。结论：长期暴露于当地交通特定的PM（PM2.5，PM10）与全身炎症的关系比总PM更密切。当地特定行业PM的协会略强，但与总PM的协会没有显着差异。引文：Hennig F，Fuks K，Moebus S，Weinmayr G，Memmesheimer M，Jakobs H，Bröcker-Preuss M，Führer-Sakel D，Möhlenkamp S，Erbel R，Jöckel KH，Hoffmann B，海因茨Nixdorf召回研究调查组。2014.特定来源颗粒物空气污染与hs-CRP之间的关联：当地交通和工业排放。环境健康展望122：703-710; http：dx.doi.org/10.1289/ehp.1307081
Background: Long-term exposures to particulate matter air pollution (PM2.5 and PM10) and high traffic load have been associated with markers of systemic inflammation. Epidemiological investigations have focused primarily on total PM, which represents a mixture of pollutants originating from different sources. Objective: We investigated associations between source-specific PM and high-sensitive C-reactive protein (hs-CRP), an independent predictor of cardiovascular disease. Methods: We used data from the first (2000–2003) and second examination (2006–2008) of the Heinz Nixdorf Recall study, a prospective population-based German cohort of initially 4,814 participants (45–75 years of age). We estimated residential long-term exposure to local traffic- and industry-specific fine particulate matter (PM2.5) at participants’ residences using a chemistry transport model. We used a linear mixed model with a random participant intercept to estimate associations of source-specific PM and natural log-transformed hs-CRP, controlling for age, sex, education, body mass index, low- and high-density lipoprotein cholesterol, smoking variables, physical activity, season, humidity, and city (8,204 total observations). Results: A 1-μg/m3 increase in total PM2.5 was associated with a 4.53% increase in hs-CRP concentration (95% CI: 2.76, 6.33%). hs-CRP was 17.89% (95% CI: 7.66, 29.09%) and 7.96% (95% CI: 3.45, 12.67%) higher in association with 1-μg/m3 increases in traffic- and industry-specific PM2.5, respectively. Results for PM10 were similar. Conclusions: Long-term exposure to local traffic-specific PM (PM2.5, PM10) was more strongly associated with systemic inflammation than total PM. Associations of local industry-specific PM were slightly stronger but not significantly different from associations with total PM. Citation: Hennig F, Fuks K, Moebus S, Weinmayr G, Memmesheimer M, Jakobs H, Bröcker-Preuss M, Führer-Sakel D, Möhlenkamp S, Erbel R, Jöckel KH, Hoffmann B, Heinz Nixdorf Recall Study Investigative Group. 2014. Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissions. Environ Health Perspect 122:703–710; http://dx.doi.org/10.1289/ehp.1307081
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DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
24
作者：
Erbel, Raimund;Moehlenkamp, Stefan;Joeckel, Karl-Heinz
通讯作者：
Joeckel, Karl-Heinz
影响因子：
5.4
作者：
Forbes, Lindsay J. L.;Patel, Minal D.;Anderson, Ross H.
通讯作者：
Anderson, Ross H.
动脉粥样硬化的炎症。
DOI：
10.1161/atvbaha.108.179705
发表时间：
2012-09
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Libby P
通讯作者：
Libby P
影响因子：
10.4
作者：
Hoffmann B;Moebus S;Dragano N;Stang A;Möhlenkamp S;Schmermund A;Memmesheimer M;Bröcker-Preuss M;Mann K;Erbel R;Jöckel KH
通讯作者：
Jöckel KH