Nitrogen narcosis induced by repetitive hyperbaric nitrogen oxygen mixture exposure impairs long-term cognitive function in newborn mice.
Nitrogen narcosis induced by repetitive hyperbaric nitrogen oxygen mixture exposure impairs long-term cognitive function in newborn mice.
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反复接触高压氮氧混合物引起的氮麻醉损害新生小鼠的长期认知功能
DOI：
10.1371/journal.pone.0196611
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Jiang ZL
中科院分区：
文献类型：
--
作者：
Peng B;Peng SH;Qu RM;Xu LH;Jiang ZL
人体暴露于压缩空气或氮氧混合物中，会产生氮麻醉的体征和症状，如失忆甚至丧失记忆，一旦回到常压环境，这些症状可能会消失。本研究旨在探讨重复高压氮氧混合气暴露诱导的氮麻醉对新生小鼠长期认知功能的影响及其机制。成年小鼠在0.6、1.2、1.8MPa（百万帕）氮氧混合气中暴露时，脑电频率降低，波幅增加，呈压力依赖性。出生后7-9天的小鼠，而不是在成年小鼠重复高压暴露诱导的氮麻醉延长的潜伏期，以找到平台，减少平台的网站交叉在Morris水迷宫测试的数量，并减少在开放领域的测试中的中心的时间。在高压暴露后的第一天，立即观察到海马和皮质中裂解的caspase-3的表达增加，并持续了7天。此外，氮麻醉诱导的树突棘的损失，但不是神经元，这可能是主要的认知功能障碍。氮麻醉可引起出生后小鼠的长期认知和情绪功能障碍，但成年小鼠则无，这可能是由于神经元凋亡，尤其是神经元树突棘减少所致。
Human beings are exposed to compressed air or a nitrogen-oxygen mixture, they will produce signs and symptoms of nitrogen narcosis such as amnesia or even loss of memory, which may be disappeared once back to the normobaric environment. This study was designed to investigate the effect of nitrogen narcosis induced by repetitive hyperbaric nitrogen-oxygen mixture exposure on long-term cognitive function in newborn mice and the underlying mechanisms. The electroencephalogram frequency was decreased while the amplitude was increased in a pressure-dependent manner during 0.6, 1.2, 1.8 MPa (million pascal) nitrogen-oxygen mixture exposures in adult mice. Nitrogen narcosis in postnatal days 7–9 mice but not in adult mice induced by repetitive hyperbaric exposure prolonged the latency to find the platform and decreased the number of platform-site crossovers during Morris water maze tests, and reduced the time in the center during the open field tests. An increase in the expression of cleaved caspase-3 in the hippocampus and cortex were observed immediately on the first day after hyperbaric exposure, and this lasted for seven days. Additionally, nitrogen narcosis induced loss of the dendritic spines but not of the neurons, which may mainly account for the cognitive dysfunction. Nitrogen narcosis induced long-term cognitive and emotional dysfunction in the postnatal mice but not in the adult mice, which may result from neuronal apoptosis and especially reduction of dendritic spines of neurons.
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影响因子：
3.7
作者：
Platholi J;Herold KF;Hemmings HC Jr;Halpain S
通讯作者：
Halpain S
影响因子：
3.3
作者：
Freiberger, J. J.;Derrick, B. J.;Moon, R. E.
通讯作者：
Moon, R. E.
DOI：
10.1001/archpedi.1953.02050080600004
发表时间：
1953-01-01
期刊：
AMA AMERICAN JOURNAL OF DISEASES OF CHILDREN
影响因子：
--
作者：
ECKENHOFF, JE
通讯作者：
ECKENHOFF, JE
影响因子：
2.7
作者：
Schmidt, M.;Brandwein, C.;Gass, P.
通讯作者：
Gass, P.
影响因子：
3.5
作者：
Buchanan TW;Tranel D;Kirschbaum C
通讯作者：
Kirschbaum C