Surrogate marker of preclinical tuberculosis in human immunodeficiency virus infection: antibodies to an 88-kDa secreted antigen of Mycobacterium tuberculosis.
Surrogate marker of preclinical tuberculosis in human immunodeficiency virus infection: antibodies to an 88-kDa secreted antigen of Mycobacterium tuberculosis.
复制标题
人类免疫缺陷病毒感染中临床前结核病的替代标志物：针对结核分枝杆菌 88 kDa 分泌抗原的抗体。
DOI：
10.1086/514015
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Zolla-Pazner,S
中科院分区：
文献类型：
--
作者：
Laal,S;Samanich,KM;Sonnenberg,MG;Belisle,JT;O'Leary,J;Simberkoff,MS;Zolla-Pazner,S
Antibodies to purified, size-fractionated secreted proteins ofMycobacterium tuberculosisin sera from patients with human immunodeficiency virus (HIV) infection and active tuberculosis (HIV/TB patients), and in stored sera obtained from the same patients prior to clinical manifestation of TB, were evaluated by ELISA, and the repertoire of antigens recognized was analyzed by immunoblotting. Compared with non-HIV/TB patients, HIV/TB patients had lower levels of anti-mycobacterial antibodies, and these were directed toward a restricted set of antigens. Antibodies to an 88-kDa secreted antigen were present in the sera of 74% of HIV/TB patients during the years (1.5–6) prior to manifestation of active, clinical tuberculosis, although only 66% were positive by the time tuberculosis was diagnosed. The presence of antibodies to the 88-kDa antigen can serve as a surrogate marker for identifying HIV-infected persons with active, subclinical disease who are at a high risk of developing clinical tuberculosis.
登录
查看更多内容
A60抗原ELISA在活动性肺结核诊断中的价值
DOI：
--
发表时间：
1990
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
D. Charpin;H. Herbault;M. Gevaudan;M. Saadjian;P. de Micco;A. Arnaud;D. Vervloet;J. Charpin
通讯作者：
J. Charpin
HIV 感染者和未感染者的结核病患者中免疫球蛋白 G 亚类对分枝杆菌脂阿拉伯甘露聚糖的反应
影响因子：
4.6
作者：
Christopher da Costa;S. Khanolkar;A. Elliott;K. Wasunna;K. McAdam
通讯作者：
K. McAdam
影响因子：
158.5
作者：
ALLAND, D;KALKUT, GE;BLOOM, BR
通讯作者：
BLOOM, BR
影响因子：
158.5
作者：
SMALL, PM;HOPEWELL, PC;SCHOOLNIK, GK
通讯作者：
SCHOOLNIK, GK
影响因子：
4.4
作者：
E. Janoff;W. Hardy;P. D. Smith;S. Wahl
通讯作者：
E. Janoff;W. Hardy;P. D. Smith;S. Wahl