Models of Replicator Proliferation Involving Differential Replicator Subunit Stability.
Models of Replicator Proliferation Involving Differential Replicator Subunit Stability.
复制标题
DOI：
10.1007/s11084-018-9561-x
复制
发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Tower J
中科院分区：
文献类型：
--
作者：
Li Z;Lyu R;Tower J
生命起源的几种模型涉及能够自我复制的分子，例如由RNA或DNA或氨基酸组成的自我复制聚合物。在这里，我们考虑一个假设的复制子（AB）由两个亚基，A和B。用Python和C编程语言编写的程序用于在指定的假设条件下将AB复制子丰度建模为复制周期（迭代）的函数。两个非排他性模型描述了B相对于A的降低的稳定性如何通过产生游离A亚基而对复制子活性和/或进化具有优势。在模型1中，游离的A亚基与AB复制子结合以产生具有更大活性的AAB复制子。在模拟中，当AAB的复制活性大于AB的复制活性的两倍时，降低B的稳定性是有益的。在模型2中，空闲的A子单元在重新创建B子单元之前在一定数量的迭代中是不活动的。A重新产生B亚基，产生B或B '的机会相等，其中B'是相对于AB增加AB'复制子活性的突变体。在模拟中，在中等数量的迭代（< 15）下，当B的稳定性大于A的不活动时间时，B的较短存活时间是有益的。结果是一致的假设，减少稳定性的复制子亚基可以在适当的条件下是有利的。
Several models for the origin of life involve molecules that are capable of self-replication, such as self-replicating polymers composed of RNA or DNA or amino acids. Here we consider a hypothetical replicator (AB) composed of two subunits, A and B. Programs written in Python and C programming languages were used to model AB replicator abundance as a function of cycles of replication (iterations), under specified hypothetical conditions. Two non-exclusive models describe how a reduced stability for B relative to A can have an advantage for replicator activity and/or evolution by generating free A subunits. In model 1, free A subunits associate with AB replicators to create AAB replicators with greater activity. In simulations, reduced stability of B was beneficial when the replication activity of AAB was greater than two times the replication activity of AB. In model 2, the free A subunit is inactive for some number of iterations before it re-creates the B subunit. A re-creates the B subunit with an equal chance of creating B or B’, where B’ is a mutant that increases AB’ replicator activity relative to AB. In simulations, at moderate number of iterations (< 15), a shorter survival time for B is beneficial when the stability of B is greater than the inactive time of A. The results are consistent with the hypothesis that reduced stability for a replicator subunit can be advantageous under appropriate conditions.
登录
查看更多内容
DOI：
10.1073/pnas.1610103113
发表时间：
2016-08-30
影响因子：
11.1
作者：
Horning, David P.;Joyce, Gerald F.
通讯作者：
Joyce, Gerald F.
影响因子：
56.9
作者：
Johnston, WK;Unrau, PJ;Bartel, DP
通讯作者：
Bartel, DP
影响因子：
--
作者：
GRAY, P;SCOTT, SK
通讯作者：
SCOTT, SK
影响因子：
--
作者：
EIGEN, M;SCHUSTER, P
通讯作者：
SCHUSTER, P
影响因子：
2
作者：
Cleland, CE;Chyba, CF
通讯作者：
Chyba, CF