Serotonin attenuates a slow inhibitory postsynaptic potential in rat hippocampal neurons
Serotonin attenuates a slow inhibitory postsynaptic potential in rat hippocampal neurons
复制标题
血清素减弱大鼠海马神经元的缓慢抑制性突触后电位
DOI：
10.1016/0306-4522(90)90006-p
复制
发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
M. Segal
中科院分区：
文献类型：
--
作者：
M. Segal
在离体切片上记录海马神经元的活动。局部应用5-羟色胺产生超极化，阻滞一个缓慢的后超极化，随后爆发性放电和阻滞一个缓慢的抑制性突触后电位。刺激海马顶端树突区诱发的慢抑制性突触后电位对5-羟色胺的反应比膜电位或电导更敏感。5-羟色胺对抑制性突触后电位的作用可被5-HT_（1A）拮抗剂螺哌隆阻断，而不被5-HT_（2A）拮抗剂米安色林阻断。抑制性突触后电位的衰减并不伴随着对GABA或巴氯芬的突触后反应性的变化。5-羟色胺阻断局部应用4-氨基吡啶诱发的海马神经元重复性大抑制性突触后电位。假定的中间神经元比锥体神经元对局部应用5-羟色胺更敏感。芬氟拉明是一种5-羟色胺释放剂，它模拟了局部应用5-羟色胺的作用，表明突触释放的5-羟色胺可以引起膜电位和对传入刺激的反应性的变化。这表明，5-羟色胺衰减慢抑制性突触后电位通过抑制前馈抑制性中间神经元冲击记录的锥体神经元。
Activity of hippocampal neurons was recorded in anin vitroslice preparation. Topical application of serotonin produced hyperpolarization, blockade of a slow afterhyperpolarization which follows a burst discharge and blockade of a slow inhibitory postsynaptic potential. The slow inhibitory postsynaptic potential evoked by stimulation of the apical dendritic region of the hippocampus is more sensitive to serotonin than the membrane potential or conductance. The effects of serotonin on the inhibitory postsynaptic potentials are blocked by the 5-HT1Aantagonist spiperone, and not by mianserin, a 5-HT2antagonist. The attenuation of the inhibitory postsynaptic potentials is not accompanied by a change in postsynaptic reactivity to GABA or baclofen. Serotonin blocks repetitive large inhibitory postsynaptic potentials evoked in hippocampal neurons by topical application of 4-aminopyridine. Putative interneurons are more sensitive to topical application of serotonin than pyramidal neurons. Fenfluramine, a serotonin releaser mimics the effects of topical application of serotonin indicating that synaptically released serotonin can produce the changes in membrane potential and reactivity to afferent stimulation. It is suggested that serotonin attenuates slow inhibitory postsynaptic potentials by inhibiting feed forward inhibitory interneurons which impinge upon the recorded pyramidal neurons.
海马 CA3 神经元晚期突触超极化的电导变化。
影响因子：
2.5
作者：
Hablitz,JJ;Thalmann,RH
通讯作者：
Thalmann,RH
中缝核对穿通通路通过齿状回的神经元传递的影响。
影响因子：
2.5
作者：
Winson,J
通讯作者：
Winson,J
影响因子：
56.9
作者：
ANDRADE, R;MALENKA, RC;NICOLL, RA
通讯作者：
NICOLL, RA