The Use of a Three-Fluid Atomising Nozzle in the Production of Spray-Dried Theophylline/Salbutamol Sulphate Powders Intended for Pulmonary Delivery.
The Use of a Three-Fluid Atomising Nozzle in the Production of Spray-Dried Theophylline/Salbutamol Sulphate Powders Intended for Pulmonary Delivery.
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DOI：
10.3390/pharmaceutics12111116
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发表时间：
2020-11-20
期刊：
影响因子：
5.4
通讯作者：
Healy AM
中科院分区：
文献类型：
--
作者：
Focaroli S;Jiang G;O'Connell P;Fahy JV;Healy AM
The aim of this study was to investigate the use of a three-fluid atomising nozzle in a lab-scale spray dryer for the production of dry powders intended for pulmonary delivery. Powders were composed of salbutamol sulphate and theophylline in different weight ratios. The three-fluid nozzle technology enabled powders containing a high theophylline content to be obtained, overcoming the problems associated with its relatively low solubility, by pumping two separate feed solutions (containing the two different active pharmaceutical ingredients (APIs)) into the spray dryer via two separate nozzle channels at different feed rates. The final spray-dried products were characterized in terms of morphology, solid-state properties and aerosolization performance, and were compared with an equivalent formulation prepared using a standard two-fluid atomising nozzle. Results confirmed that most of the powders made using the three-fluid atomising nozzle met the required standards for a dry powder inhaler formulation in terms of physical characteristics; however, aerosolization characteristics require improvement if the powders are to be considered suitable for pulmonary delivery.
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影响因子：
5.8
作者：
Amaro, Maria Ines;Tajber, Lidia;Healy, Anne Marie
通讯作者：
Healy, Anne Marie
影响因子：
5.8
作者：
Bianco, Stefano;Tewes, Frederic;Healy, Anne Marie
通讯作者：
Healy, Anne Marie
DOI：
10.1513/pats.200504-024sr
发表时间：
2005-01-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Barnes, Peter J
通讯作者：
Barnes, Peter J
影响因子：
3.9
作者：
Legako, Jerrad;Dunford, Nurhan Turgut
通讯作者：
Dunford, Nurhan Turgut
影响因子：
3.7
作者：
HANCOCK, BC;SHAMBLIN, SL;ZOGRAFI, G
通讯作者：
ZOGRAFI, G