Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage.
Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage.
复制标题
蛛网膜下腔出血后继发性脑白质损伤及治疗靶点
DOI：
10.3389/fneur.2021.659740
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Feng H
中科院分区：
文献类型：
--
作者：
Ru X;Gao L;Zhou J;Li Q;Zuo S;Chen Y;Liu Z;Feng H
动脉瘤性蛛网膜下腔出血（SAH）是一种特殊的脑卒中亚型，具有较高的死亡率和活动性。尽管由于神经外科和神经重症监护管理的进步，SAH的死亡率在过去二十年中下降了50%，但超过70%的幸存者患有不同程度的神经功能缺损和认知障碍，给个人、家庭和社会留下了沉重的负担。近年来的研究表明，白色物质易受SAH的影响，白色物质损伤可能是SAH导致长期神经功能缺损的原因之一。白色物质损伤在SAH后的病理生理过程中起着关键作用，主要与脑内压升高引起的机械损伤和血液降解和缺氧引起的代谢损伤有关。本文就SAH后白色损害的病理生理过程及机制进行综述，以期为SAH后长期认知功能障碍的防治提供新的策略。
Aneurysmal subarachnoid hemorrhage (SAH) is one of the special stroke subtypes with high mortality and mobility. Although the mortality of SAH has decreased by 50% over the past two decades due to advances in neurosurgery and management of neurocritical care, more than 70% of survivors suffer from varying degrees of neurological deficits and cognitive impairments, leaving a heavy burden on individuals, families, and the society. Recent studies have shown that white matter is vulnerable to SAH, and white matter injuries may be one of the causes of long-term neurological deficits caused by SAH. Attention has recently focused on the pivotal role of white matter injury in the pathophysiological processes after SAH, mainly related to mechanical damage caused by increased intracerebral pressure and the metabolic damage induced by blood degradation and hypoxia. In the present review, we sought to summarize the pathophysiology processes and mechanisms of white matter injury after SAH, with a view to providing new strategies for the prevention and treatment of long-term cognitive dysfunction after SAH.
登录
查看更多内容
影响因子：
5.3
作者：
Abiraman, Kavitha;Pol, Suyog U.;Sim, Fraser J.
通讯作者：
Sim, Fraser J.
头孢曲松通过 PI3K/AKT/NF-kappa B 信号通路增加兴奋性氨基酸转运蛋白 2 的表达，减轻蛛网膜下腔出血后的早期脑损伤
影响因子：
3.3
作者：
Feng, D.;Wang, W.;Qin, H.
通讯作者：
Qin, H.
影响因子：
8.3
作者：
Egashira Y;Zhao H;Hua Y;Keep RF;Xi G
通讯作者：
Xi G
影响因子：
4.4
作者：
Domercq, Maria;Sanchez-Gomez, Maria Victoria;Matute, Carlos
通讯作者：
Matute, Carlos
影响因子：
--
作者：
de Castro, F;Bribián, A
通讯作者：
Bribián, A