Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned Parkinson's Disease Rat Model.
Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned Parkinson's Disease Rat Model.
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跑步机运动对 6-OHDA 损伤帕金森病大鼠模型中多巴胺能神经元损失和肌肉萎缩恢复的影响。
DOI：
10.4196/kjpp.2012.16.5.305
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Jeon S
中科院分区：
文献类型：
--
作者：
Choe MA;Koo BS;An GJ;Jeon S
本研究旨在观察运动对6-羟基多巴胺（6-OHDA）诱导的帕金森病模型多巴胺能神经元丢失和肌肉萎缩恢复的影响。在6-OHDA毁损后第5天，每天进行2次负荷运动，每次30分钟，并在跑步机上持续16天。与对照组相比，运动组大鼠黑质酪氨酸羟化酶阳性神经元数量和纹状体酪氨酸羟化酶表达水平显著增加。为了检查哪些信号通路可能参与运动，在纹状体中观察了GSK 3 β和ERK的磷酸化。结果表明，运动可通过磷酸化途径抑制GSK 3 β的活性，这可能与运动对6-OHDA诱导的细胞死亡的保护作用有关。在运动组，重量，和对侧比目鱼肌的I型和II型纤维横截面积显着恢复和肌球蛋白重链和Akt和ERK磷酸化的表达显着增加运动。这些结果表明，运动恢复帕金森病引起的多巴胺能神经元的损失和对侧比目鱼肌萎缩。
This study was to determine the effect of exercise on the recovery of dopaminergic neuron loss and muscle atrophy in 6-OHDA-induced hemi Parkinson's disease model. Exercise was loaded twice per day for 30 minutes each time, at 5 days after 6-OHDA lesioning and continued for 16 days using a treadmill. Exercise significantly increased the number of tyrosine hydroxylase positive neuron in the lesioned substantia nigra and the expression level of tyrosine hydroxylase in the striatum compared with the control group. To examine which signaling pathways may be involved in the exercise, the phosphorylation of GSK3β and ERK were observed in the striatum. In the control group, basal level of GSK3β phosphorylation was less than in both striatum, but exercise increased it. ERK phosphorylation decreased in the lesioned striatum, but exercise recovered it. These findings suggest that exercise inactivates GSK3β by phosphorylation which may be involved in the neuroprotective effect of exercise on the 6-OHDA-induced cell death. In the exercise group, weight, and Type I and II fiber cross-sectional area of the contralateral soleus significantly recovered and expression of myosin heavy chain and Akt and ERK phosphorylation significantly increased by exercise. These results suggest that exercise recovers Parkinson's disease induced dopaminergic neuron loss and contralateral soleus muscle atrophy.
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影响因子：
3.3
作者：
Bigard, XA;Janmot, C;DAlbis, A
通讯作者：
DAlbis, A
DOI：
10.1046/j.1440-1681.2001.03544.x
发表时间：
2001-11-01
影响因子：
2.9
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5.1
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