Distinct modes of functional connectivity induced by movie-watching.
Distinct modes of functional connectivity induced by movie-watching.
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DOI：
10.1016/j.neuroimage.2018.09.042
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发表时间：
2019-01-01
期刊：
影响因子：
5.7
通讯作者：
Deco G
中科院分区：
文献类型：
--
作者：
Demirtaş M;Ponce-Alvarez A;Gilson M;Hagmann P;Mantini D;Betti V;Romani GL;Friston K;Corbetta M;Deco G
系统神经科学中的一个基本问题是，在特定的大脑状态下，内源性神经元活动是如何自我组织的。最近的神经成像研究证实了静息状态和任务诱导的功能连接(FC)之间的系统关系。特别是，持续的任务研究，如看电影，表明与静息状态相比，大脑皮层区域之间耦合的变化和FC的波动增强。这表明，FC可能反映了被试在观看电影时对功能整合反应的系统性和大规模重组。在这项研究中，我们描述了静息状态和看电影条件下FC的波动。我们发现，系统地由看电影引起的FC模式可以用单个主成分来解释。这些条件特定的FC波动与枕叶和颞叶脑区受试者之间的同步模式重叠。然而，与受试者之间的同步不同，条件特定的FC模式的特征是额叶大脑区域内的相关性增加，而额叶-顶叶大脑区域之间的相关性降低。我们使用时间分辨的FC，在较短的时间尺度上研究了这些条件特定的函数变化。时间分辨的FC随着时间的推移表现出条件特异性；特别是当受试者同时观看相同和不同的电影时。为了通过局部动力学的变化来解释全球FC的自组织，我们使用了一个大规模的计算模型。我们发现，条件特异性的FC重组可以通过局部变化来解释，这些变化导致了高阶关联区之间FC的变化，主要是在额叶和顶叶皮质。
A fundamental question in systems neuroscience is how endogenous neuronal activity self- organizes during particular brain states. Recent neuroimaging studies have demonstrated systematic relationships between resting-state and task-induced functional connectivity (FC). In particular, continuous task studies, such as movie watching, speak to alterations in coupling among cortical regions and enhanced fluctuations in FC compared to the resting- state. This suggests that FC may reflect systematic and large-scale reorganization of functionally integrated responses while subjects are watching movies. In this study, we characterized fluctuations in FC during resting-state and movie-watching conditions. We found that the FC patterns induced systematically by movie-watching can be explained with a single principal component. These condition-specific FC fluctuations overlapped with inter-subject synchronization patterns in occipital and temporal brain regions. However, unlike inter-subject synchronization, condition-specific FC patterns were characterised by increased correlations within frontal brain regions and reduced correlations between frontal-parietal brain regions. We investigated these condition-specific functional variations as a shorter time scale, using time-resolved FC. The time-resolved FC showed condition- specificity over time; notably when subjects watched both the same and different movies. To explain self-organisation of global FC through the alterations in local dynamics, we used a large-scale computational model. We found that condition-specific reorganization of FC could be explained by local changes that engendered changes in FC among higher-order association regions, mainly in frontal and parietal cortices.
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影响因子：
3.4
作者：
Carbonell, Felix;Bellec, Pierre;Shmuel, Amir
通讯作者：
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DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
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作者：
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