Effect of Cevimeline on Salivary Components in Patients with Sjögren Syndrome
Effect of Cevimeline on Salivary Components in Patients with Sjögren Syndrome
复制标题
西维美林对干燥综合征患者唾液成分的影响
作者：
Kimihiro Suzuki;Mitsuyo Matsumoto;M. Nakashima;K. Takada;T. Nakanishi;M. Okada;F. Ohsuzu
本研究的目的是阐明西维美林对人唾液中免疫球蛋白A（伊加）、溶菌酶、α-淀粉酶和鳞状细胞癌（SCC）抗原的影响。12例干燥综合征（SS）女性患者和14例健康女性入选。在第一次唾液采集后，向每名受试者给予一粒西维美林胶囊（30 mg）。90 min后再次收集唾液。测量唾液流速和各组分的浓度。西维美林能显著增加两组患者的唾液流速和淀粉酶浓度。溶菌酶和伊加浓度在两组中没有显著变化。SCC抗原浓度在SS组中没有显著变化，但在对照组中显著降低。淀粉酶和伊加的分泌率在两组中均显著增加。溶菌酶分泌率仅在对照组中显著增加，而SCC分泌率仅在SS组中显著增加。头孢美林不仅增加唾液流速，而且增加一些消化和/或防御感染因子的分泌速率。SS患者继续服用西维美林可能有益于预防口腔感染和其他严重后遗症。
The aim of this study is to clarify the effects of cevimeline on various components in human saliva, such as immunoglobulin A (IgA), lysozyme, α-amylase and squamous cell carcinoma (SCC) antigen. Twelve female patients with Sjögren syndrome (SS) and 14 healthy women were enrolled. After the first saliva collection, one capsule (30 mg) of cevimeline was administered to each subject. Saliva was collected again after 90 min. The salivary flow rate and concentration of each component were measured. In both groups the salivary flow rate and amylase concentration were significantly increased by cevimeline. The lysozyme and IgA concentrations did not change significantly in both groups. The SCC antigen concentration did not change significantly in the SS group, but it decreased significantly in the control group. The secretion rates of amylase and IgA showed significant increases in both groups. The secretion rate of lysozyme significantly increased only in the control group, while the secretion rate of SCC significantly increased only in the SS group. Cevimeline augments not only the salivary flow rate but also the secretion rate of some digestive and/or defense factors from infections. It may be beneficial for SS patients to continue taking cevimeline to prevent oral infections, and other serious sequelae.
DOI：
10.1016/s0021-9258(19)39678-4
发表时间：
1990-03
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
P. A. Raj;M. Edgerton;Michael J. Levine
通讯作者：
P. A. Raj;M. Edgerton;Michael J. Levine
人唇唾液腺毒蕈碱乙酰胆碱受体的表征。
影响因子：
5
作者：
Mei,L;Roeske,WR;Izutsu,KT;Yamamura,HI
通讯作者：
Yamamura,HI