Characteristics, adverse events, and racial differences among delivering mothers with peripartum cardiomyopathy.
Characteristics, adverse events, and racial differences among delivering mothers with peripartum cardiomyopathy.
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DOI：
10.1016/j.jchf.2013.04.011
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Lindenfeld J
中科院分区：
文献类型：
--
作者：
Kao DP;Hsich E;Lindenfeld J
To identify clinical features associated with peripartum cardiomyopathy (PPCM) and possible racial differences, and to quantify in-hospital outcomes in delivering mothers with PPCM. Investigation of patient characteristics and outcomes in PPCM has been limited to small cohorts. Hospital discharge data allows assembly of the largest number of PPCM cases to date. Hospital records from six states were screened for PPCM. Clinical profiles, maternal, and fetal outcomes in delivering mothers with and without PPCM were compared and stratified by race. A maternal major adverse event (MAE) was defined as death, cardiac arrest, heart transplantation, or mechanical circulatory support. Logistic regression was used to identify variables associated with PPCM. In total, 535/4,003,914 records of delivering mothers specified a diagnosis of PPCM. Prevalence of PPCM was highest among African-Americans and similar in Caucasians and Hispanics. Established risk factors including age ≥ 30 years, African-American race, hypertension, preeclampsia/eclampsia, and multigestational status were associated with PPCM, and novel associations such as anemia and asthma were identified. Autoimmune disease and substance abuse, which can cause cardiomyopathy independently, were also associated with PPCM. Maternal MAE (odds ratio=436, p<0.0001) and stillbirth (odds ratio=3.8, p<0.0001) occurred more frequently among women with PPCM. The prevalence of PPCM at the time of delivery in Hispanics was similar to Caucasians and lower than African-Americans. Autoimmune disease, substance abuse, anemia and asthma were conditions associated with PPCM not consistently identified in smaller cohorts. PPCM was also associated with increased risk of stillbirth and maternal MAEs at delivery.
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影响因子：
18.2
作者：
Sliwa, Karen;Hilfiker-Kleiner, Denise;McMurray, John J. V.
通讯作者：
McMurray, John J. V.
影响因子：
37.8
作者：
Sliwa, K;Damasceno, A;Mayosi, BM
通讯作者：
Mayosi, BM
影响因子：
1.7
作者：
Maisch, B;Richter, A;Pankuweit, S
通讯作者：
Pankuweit, S
影响因子：
7.2
作者：
Gunderson, Erica P.;Croen, Lisa A.;Go, Alan S.
通讯作者：
Go, Alan S.
影响因子：
37.8
作者：
Sliwa, Karen;Blauwet, Lori;Hilfiker-Kleiner, Denise
通讯作者：
Hilfiker-Kleiner, Denise