Sneaking-ligand fusion proteins attenuate serum transfer arthritis by endothelium-targeted NF-κB inhibition.
Sneaking-ligand fusion proteins attenuate serum transfer arthritis by endothelium-targeted NF-κB inhibition.
复制标题
潜行配体融合蛋白通过内皮靶向 NF-κB 抑制来减轻血清转移关节炎。
DOI：
10.1007/978-1-4939-2422-6_34
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Voll,ReinhardE
中科院分区：
文献类型：
--
作者：
Sehnert,Bettina;Burkhardt,Harald;May,MichaelJ;Zwerina,Jochen;Voll,ReinhardE
核转录因子κB（NF-κB）是炎症和免疫反应的重要介质。NF-κB的异常调节在关节炎发病机制中的作用已得到证实。因此，NF-κB代表了用于开发炎性疾病中的治疗干预的有吸引力的分子靶标。然而，普遍存在的NF-κB活性的药物抑制受到毒副作用和严重免疫抑制的限制。用“潜行配体”方法抑制细胞类型特异性NF-κB可以识别疾病相关的细胞类型，并提高治疗干预的风险效益比。血管内皮细胞作为一个看门人，是至关重要的白细胞招募到炎症部位。内皮特异性NF-κB抑制剂SLC 1可改善小鼠血清转移性关节炎，并防止炎症和软骨破坏。在本章中，我们描述了SLC 1治疗K/BxN血清转移性关节炎的方案，并提出了评估系统来分析关节炎的严重程度和组织病理学改变。
The nuclear transcription factor κB (NF-κB) is a crucial mediator of the inflammatory and immune response. The contribution of dysregulated NF-κB is established in the pathogenesis of arthritis. Accordingly, NF-κB represents an attractive molecular target for the development of therapeutic interventions in inflammatory diseases. However, ubiquitous pharmacologic suppression of NF-κB activity is limited by the hazards of toxic side effects and profound immunosuppression. Cell type-specific NF-κB inhibition with the “sneaking-ligand” approach could identify disease-relevant cell types and improve risk-benefit ratios of therapeutic interventions. Vascular endothelial cells act as a gatekeeper and are crucial for leukocyte recruitment into sites of inflammation. The endothelium-specific NF-κB inhibitor SLC1 ameliorates serum transfer arthritis in mice and protects against inflammation and cartilage destruction. In this chapter, we describe the SLC1 treatment schedule in theK/BxNserum transfer arthritis and present the evaluation system to analyze arthritis severity and histopathological alterations.
影响因子：
16.8
作者：
Williams MR;Azcutia V;Newton G;Alcaide P;Luscinskas FW
通讯作者：
Luscinskas FW
DOI：
10.1073/pnas.1218219110
发表时间：
2013-10-08
影响因子：
11.1
作者：
Sehnert, Bettina;Burkhardt, Harald;Voll, Reinhard Edmund
通讯作者：
Voll, Reinhard Edmund
影响因子：
4.4
作者：
K. Terato;K. Hasty;R. Reife;M. Cremer;A. Kang;J. Stuart
通讯作者：
K. Terato;K. Hasty;R. Reife;M. Cremer;A. Kang;J. Stuart