Activators and Inhibitors of Protein Kinase C (PKC): Their Applications in Clinical Trials.
Activators and Inhibitors of Protein Kinase C (PKC): Their Applications in Clinical Trials.
复制标题
DOI：
10.3390/pharmaceutics13111748
复制
发表时间：
2021-10-20
期刊：
影响因子：
5.4
通讯作者：
Kang JH
中科院分区：
文献类型：
--
作者：
Kawano T;Inokuchi J;Eto M;Murata M;Kang JH
蛋白激酶C（PKC）是磷脂依赖性丝氨酸/苏氨酸激酶的一个家族，根据其结构和活化特征可分为三个亚家族：常规或经典PKC同工酶（cPKC; α、βI、βII和γ）、新型或非经典PKC同工酶（nPKC; δ、ε、η和θ）和非典型PKC同工酶（aPKC; α、β I和λ）。PKC抑制剂和激活剂用于了解PKC介导的细胞内信号传导途径，并用于诊断和治疗各种PKC相关疾病，如癌症，神经系统疾病，心血管疾病和感染。许多PKC抑制剂在癌症中的临床试验显示没有显著的临床益处，这意味着设计单独靶向PKC的癌症治疗策略存在局限性。本文就蛋白激酶C的激活剂和抑制剂及其临床应用作一综述。
Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or non-classic PKC isozymes (nPKCs; δ, ε, η, and θ), and atypical PKC isozymes (aPKCs; ζ, ι, and λ). PKC inhibitors and activators are used to understand PKC-mediated intracellular signaling pathways and for the diagnosis and treatment of various PKC-associated diseases, such as cancers, neurological diseases, cardiovascular diseases, and infections. Many clinical trials of PKC inhibitors in cancers showed no significant clinical benefits, meaning that there is a limitation to design a cancer therapeutic strategy targeting PKC alone. This review will focus on the activators and inhibitors of PKC and their applications in clinical trials.
登录
查看更多内容
影响因子：
12.8
作者：
Barr, Paul M.;Lazarus, Hillard M.;Cooper, Brenda W.;Schluchter, Mark D.;Panneerselvam, Ashok;Jacobberger, James W.;Hsu, Jack W.;Janakiraman, Nalini;Simic, Aleksandra;Dowlati, Afshin;Remick, Scot C.
通讯作者：
Remick, Scot C.
DOI：
10.1016/s1470-2045(18)30240-7
发表时间：
2018-07
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Cortes J;Perl AE;Döhner H;Kantarjian H;Martinelli G;Kovacsovics T;Rousselot P;Steffen B;Dombret H;Estey E;Strickland S;Altman JK;Baldus CD;Burnett A;Krämer A;Russell N;Shah NP;Smith CC;Wang ES;Ifrah N;Gammon G;Trone D;Lazzaretto D;Levis M
通讯作者：
Levis M
影响因子：
20.4
作者：
Chiappori, Alberto;Bepler, Gerold;von Pawel, Joachim
通讯作者：
von Pawel, Joachim
影响因子：
7.7
作者：
Abiko, T;Abiko, A;Bursell, SE
通讯作者：
Bursell, SE
DOI：
10.1073/pnas.191369098
发表时间：
2001-09-25
影响因子：
11.1
作者：
Chen, L;Hahn, H;Mochly-Rosen, D
通讯作者：
Mochly-Rosen, D