Environmental enrichment facilitates amygdala kindling but reduces kindling-induced fear in male rats.

Environmental enrichment facilitates amygdala kindling but reduces kindling-induced fear in male rats.
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丰富的环境促进了杏仁核的点燃,但减少了雄性大鼠因点燃而产生的恐惧。

DOI:
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发表时间:
2004
影响因子:
1.9
通讯作者:
L. Kalynchuk
L. Kalynchuk
中科院分区:
医学4区
文献类型:
--
作者:
N. Young;Amanda J. Wintink;L. Kalynchuk

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本实验的目的是确定事先丰富的环境对获得点燃和点燃引起的恐惧的表达的影响。将60只雄性大鼠饲养在丰富的环境中或隔离,断奶后立即开始。作为成年人,他们接受了50次杏仁核点燃刺激或假刺激,然后在一个不熟悉的开放领域进行测试。点燃丰富的大鼠获得点燃状态比点燃隔离的大鼠更快,但他们也表现出更少的恐惧,在开放领域比点燃隔离的大鼠。这些结果表明,丰富的环境有不同的影响点燃收购及其行为后果。
The purpose of this experiment was to determine the effect of prior environmental enrichment on the acquisition of kindling and the expression of kindling-induced fear. Sixty male rats were housed either in an enriched environment or in isolation, starting immediately after weaning. As adults, they were subjected to either 50 amygdala-kindling stimulations or sham stimulations, followed by testing in an unfamiliar open field. The kindled-enriched rats acquired the kindled state more quickly than did the kindled-isolated rats, but they also showed less fear in the open field than did the kindled-isolated rats. These results suggest that environmental enrichment has differential effects on kindling acquisition and its behavioral consequences.
DOI: 10.1126/science.2449733
发表时间: 1988-03-04
期刊: SCIENCE
影响因子: 56.9
作者:
SUTULA, T;HE, XX;SCOTT, G
通讯作者: SCOTT, G