Yellow fever in the diagnostics laboratory.
Yellow fever in the diagnostics laboratory.
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DOI：
10.1038/s41426-018-0128-8
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发表时间：
2018-07-12
影响因子：
13.2
通讯作者：
Reusken C
中科院分区：
文献类型：
--
作者：
Domingo C;Charrel RN;Schmidt-Chanasit J;Zeller H;Reusken C
尽管有安全有效的疫苗可用，黄热病(YF)仍是流行地区的公共卫生问题。2015-2016年间，安哥拉和刚果民主共和国宣布爆发了YF的城市疫情，自2016年12月以来，巴西一直在持续暴发。令人极为关切的是，巴西存在城市传播周期的风险，并有可能蔓延到易感人群和有能力传播媒介的国家。疫苗接种仍然是应对暴发的基石，但疫苗库存量较低迫使实施了节约剂量战略，该战略迄今已在受影响的非洲国家实施，现在在巴西实施。准确的病例实验室确认对于有效的暴发控制至关重要。然而，缺乏有效的YF商业检测方法，以及血清学方法的缺陷，使得在参考实验室之外实施YF诊断具有挑战性。我们检查现有分析的优点和缺点，以确定及时和有效的实验室诊断的障碍。我们强调有必要开发新的诊断工具，以应对当前抗击YF的挑战。
Yellow fever (YF) remains a public health issue in endemic areas despite the availability of a safe and effective vaccine. In 2015–2016, urban outbreaks of YF were declared in Angola and the Democratic Republic of Congo, and a sylvatic outbreak has been ongoing in Brazil since December 2016. Of great concern is the risk of urban transmission cycles taking hold in Brazil and the possible spread to countries with susceptible populations and competent vectors. Vaccination remains the cornerstone of an outbreak response, but a low vaccine stockpile has forced a sparing-dose strategy, which has thus far been implemented in affected African countries and now in Brazil. Accurate laboratory confirmation of cases is critical for efficient outbreak control. A dearth of validated commercial assays for YF, however, and the shortcomings of serological methods make it challenging to implement YF diagnostics outside of reference laboratories. We examine the advantages and drawbacks of existing assays to identify the barriers to timely and efficient laboratory diagnosis. We stress the need to develop new diagnostic tools to meet current challenges in the fight against YF.
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DOI：
10.1128/cvi.00209-16
发表时间：
2016-08
期刊：
Clinical and vaccine immunology : CVI
影响因子：
--
作者：
Adungo F;Yu F;Kamau D;Inoue S;Hayasaka D;Posadas-Herrera G;Sang R;Mwau M;Morita K
通讯作者：
Morita K
影响因子：
3.1
作者：
Basile, Alison Jane;Goodman, Christin;Johnson, Barbara W.
通讯作者：
Johnson, Barbara W.
影响因子：
13.2
作者：
Chen, Zhihai;Liu, Lin;Lv, Yanning;Zhang, Wei;Li, Jiandong;Zhang, Yi;Di, Tian;Zhang, Shuo;Liu, Jingyuan;Li, Jie;Qu, Jing;Hua, Wenhao;Li, Chuan;Wang, Peng;Zhang, Quanfu;Xu, Yanli;Jiang, Rongmeng;Wang, Qin;Chen, Lijuan;Wang, Shiwen;Pang, Xinghuo;Liang, Mifang;Ma, Xuejun;Li, Xingwang;Wang, Quanyi;Zhang, Fujie;Li, Dexin
通讯作者：
Li, Dexin
影响因子：
3.1
作者：
Bae, HG;Nitsche, A;Niedrig, M
通讯作者：
Niedrig, M
影响因子：
3.8
作者：
Brinkmann, Annika;Erguenay, Koray;Nitsche, Andreas
通讯作者：
Nitsche, Andreas