Light therapy for bipolar disorder: a case series in women.
Light therapy for bipolar disorder: a case series in women.
复制标题
双相情感障碍的光疗法：女性病例系列。
DOI：
10.1111/j.1399-5618.2007.00451.x
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发表时间：
2007
影响因子：
5.4
通讯作者：
M. Terman
中科院分区：
文献类型：
--
作者：
D. Sit;K. Wisner;B. Hanusa;S. Stull;M. Terman
目标
对双相情感障碍（BD）女性抑郁症患者进行明亮光治疗的剂量范围安全性和有效性研究。
方法
9名患有DSM-IV BD I或II的女性在抑郁阶段暴露于50勒克斯（接收表面的照度）红光两周，之后她们接受7，000勒克斯的光治疗，每天15，30和45分钟。采用汉密尔顿抑郁量表结构化访谈指南和非典型抑郁补充量表以及躁狂量表评估情绪症状。4名患者接受早晨光照，5名患者接受中午光照。
结果
接受晨光治疗的四名受试者中有三名出现混合状态。第4例受试者获得了全面、持续的缓解。为了降低诱发混合发作的风险，我们将光照时间改为中午。在接受中午光疗法的五名妇女中，两名达到完全反应，两名显示早期改善，但需要增加剂量以维持反应。一名妇女仍然抑郁与45分钟的中午光，但完全响应切换到早晨的光，每天30分钟。
结论
患有双相情感障碍的女性对早晨明亮的光线治疗高度敏感;混合状态的诱导是一个很大的风险。对于双相抑郁症，最好在中午短暂光照（15分钟）开始治疗。
OBJECTIVES
To perform a dose-ranging safety and efficacy study of bright light therapy for depression in women with bipolar disorder (BD).
METHODS
Nine women with DSM-IV BD I or II in the depressed phase were exposed to 50 lux (illuminance at the receiving surface) red light for two weeks, after which they received 7,000 lux light therapy for two-week epochs of 15, 30 and 45 min daily. The Structured Interview Guide for the Hamilton Depression Rating Scale with Atypical Depression Supplement and the Mania Rating Scale were used to assess mood symptoms. Four patients received morning light and five patients received midday light.
RESULTS
Three of the four subjects treated with morning light developed mixed states. The fourth subject achieved a full, sustained response. To decrease the risk of inducing mixed episodes, we changed the time of light exposure to midday. Of the five women who received midday light therapy, two achieved full response and two showed early improvement but required a dose increase to sustain response. One woman remained depressed with 45 min of midday light but responded fully to a switch to morning light, 30 min daily.
CONCLUSIONS
Women with bipolar illness are highly sensitive to morning bright light treatment; the induction of mixed states is a substantial risk. Initiating treatment with a brief duration (15 min) of midday light for bipolar depression is advisable.
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影响因子：
--
作者：
Judd, LL;Akiskal, HS;Keller, MB
通讯作者：
Keller, MB
影响因子：
17.7
作者：
Altshuler, L;Suppes, T;Post, R
通讯作者：
Post, R
DOI：
--
发表时间：
1997-05
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
M. Thase;A. Rush
通讯作者：
M. Thase;A. Rush
亮光治疗作用机制的相移假说：理论考虑和实验证据。
影响因子：
--
作者：
Lewy,AJ;Sack,RL;Singer,CM;White,DM
通讯作者：
White,DM
DOI：
10.1176/ajp.148.4.509
发表时间：
1991
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Oren,DA;Brainard,GC;Johnston,SH;Joseph-Vanderpool,JR;Sorek,E;Rosenthal,NE
通讯作者：
Rosenthal,NE