System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders.
System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders.
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DOI：
10.1016/j.pneurobio.2018.07.001
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发表时间：
2018-10
影响因子：
6.7
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Gomez-Pinilla F;Yang X
高热量食物的激增导致了全球范围内代谢紊乱的流行，以至于肥胖和糖尿病患者的发病率上升令人担忧。新的研究表明，代谢紊乱会造成神经和精神疾病的风险，包括中风、阿尔茨海默病、亨廷顿舞蹈病和抑郁症，所有这些疾病都有代谢成分。这些关系根植于调节能量代谢和突触可塑性的分子过程之间功能失调的相互作用。在进化过程中，饮食因素对大脑形成的强大适应性可以通过改变细胞生物能量学和表观基因组之间的相互作用来促进大脑的长期健康。全面了解营养物质的广泛作用与大脑健康之间的关系，需要高水平的数据处理能力，以及整合来自众多分子实体和途径的信息的能力。营养系统生物学正在成为一种可行的方法来阐明细胞、组织和器官系统对饮食的反应中涉及信息处理的多个分子层。有关食物对大脑和认知可塑性引发的广泛的细胞和分子相互作用的信息对于设计公共卫生倡议以减少代谢和大脑疾病的流行至关重要。
The surge in meals high in calories has prompted an epidemic of metabolic disorders around the world such that the elevated incidence of obese and diabetic individuals is alarming. New research indicates that metabolic disorders pose a risk for neurological and psychiatric conditions including stroke, Alzheimer’s disease, Huntington’s disease, and depression, all of which have a metabolic component. These relationships are rooted to a dysfunctional interaction between molecular processes that regulate energy metabolism and synaptic plasticity. The strong adaptive force of dietary factors on shaping the brain during evolution can be manipulated to trans form the interaction between cell bioenergetics and epigenome with the aptitude to promote long-lasting brain healthiness. A thorough understanding of the association between the broad action of nutrients and brain fitness requires high level data processing empowered with the capacity to integrate information from a multitude of molecular entities and pathways. Nutritional systems biology is emerging as a viable approach to elucidate the multiple molecular layers involved in information processing in cells, tissues, and organ systems in response to diet. Information about the wide range of cellular and molecular interactions elicited by foods on the brain and cognitive plasticity is crucial for the design of public health initiatives for curtailing the epidemic of metabolic and brain disorders.
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影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
DOI：
10.1073/pnas.1012851108
发表时间：
2010-12-28
影响因子：
11.1
作者：
Caccamo, Antonella;Maldonado, Monica A.;Oddo, Salvatore
通讯作者：
Oddo, Salvatore
影响因子：
5.5
作者：
Agrawal, Rahul;Gomez-Pinilla, Fernando
通讯作者：
Gomez-Pinilla, Fernando
影响因子：
3.7
作者：
Cho, Clara E.;Sanchez-Hernandez, Diana;Anderson, G. Harvey
通讯作者：
Anderson, G. Harvey
影响因子：
4.2
作者：
Chen, Tsan-Ju;Wang, Dean-Chuan;Chen, Shun-Sheng
通讯作者：
Chen, Shun-Sheng