The Efficacy of Using Combination Therapy against Multi-Drug and Extensively Drug-Resistant Pseudomonas aeruginosa in Clinical Settings.
The Efficacy of Using Combination Therapy against Multi-Drug and Extensively Drug-Resistant Pseudomonas aeruginosa in Clinical Settings.
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DOI：
10.3390/antibiotics11030323
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发表时间：
2022-02-28
期刊：
影响因子：
--
通讯作者：
Coates A
中科院分区：
文献类型：
--
作者：
Jones F;Hu Y;Coates A
铜绿假单胞菌是一种革兰氏阴性细菌，能够产生高水平的抗生素耐药性。它已被列入世卫组织的关键优先病原体清单，常见于呼吸机相关性肺炎感染、血流感染和其他主要医院获得性疾病。这些感染由于其增加的抗生素耐药性而难以有效治疗，因此患者通常用抗生素组合方案治疗。研究方法：我们使用奥维德搜索引擎和Embase、奥维德Medline和阿帕PsycInfo数据库，按照筛选标准进行了系统性检索。结果如下：结果发现，在许多情况下，联合治疗能够匹配或优于单药治疗，并且没有一种治疗明显比单药治疗差。但临床研究多为小型研究，仅有少数为前瞻性随机临床试验，缺乏统计学意义。结论：得出的结论是，联合疗法在治疗这些高度耐药的细菌中占有一席之地，并且在某些情况下，有一些证据表明它们提供了比单一疗法更有效的治疗。
Pseudomonas aeruginosa is a Gram-negative bacterium which is capable of developing a high level of antibiotic resistance. It has been placed on the WHO’s critical priority pathogen list and it is commonly found in ventilator-associated pneumonia infections, blood stream infections and other largely hospital-acquired illnesses. These infections are difficult to effectively treat due to their increasing antibiotic resistance and as such patients are often treated with antibiotic combination regimens. Methods: We conducted a systematic search with screening criteria using the Ovid search engine and the Embase, Ovid Medline, and APA PsycInfo databases. Results: It was found that in many cases the combination therapies were able to match or outperform the monotherapies and none performed noticeably worse than the monotherapies. However, the clinical studies were mostly small, only a few were prospective randomized clinical trials and statistical significance was lacking. Conclusions: It was concluded that combination therapies have a place in the treatment of these highly resistant bacteria and, in some cases, there is some evidence to suggest that they provide a more effective treatment than monotherapies.
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