PDK1 and HR46 gene homologs tie social behavior to ovary signals.
PDK1 and HR46 gene homologs tie social behavior to ovary signals.
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DOI：
10.1371/journal.pone.0004899
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Page RE Jr
中科院分区：
文献类型：
--
作者：
Wang Y;Amdam GV;Rueppell O;Wallrichs MA;Fondrk MK;Kaftanoglu O;Page RE Jr
社会性昆虫分工的遗传基础是进化和行为生物学的核心问题。蜜蜂是研究进化行为遗传学的模型，因为它具有与年龄相关的劳动分工。在巢内任务的初始时期之后，2-3周龄的工蜂开始在巢外觅食。个体通常通过偏向于收集花粉或花蜜来进行专门化。努力解释觅食专业化的起源表明，花蜜和花粉觅食专家之间的分工是受基因的生殖生理影响。觅食行为的数量性状基因座（QTL）定位也揭示了生殖性状的候选基因。在这里，我们解决的链接生殖解剖行为，使用回交QTL分析，行为和解剖表型，候选基因表达研究，并回交确认基因解剖性状协会。我们的数据首次表明，两个位置候选基因的行为，PDK 1和HR 46的活动，有直接的遗传关系，卵巢大小，一个中心的生殖性状，与花蜜和花粉觅食的工人的偏见。这些发现暗示了两个以前不知道的影响复杂社会行为的基因。此外，他们还概述了选择如何作用于影响生殖资源分配和行为的基因网络，以促进蜜蜂社会觅食的进化。
The genetic basis of division of labor in social insects is a central question in evolutionary and behavioral biology. The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor. After an initial period of within-nest tasks, 2–3 week-old worker bees begin foraging outside the nest. Individuals often specialize by biasing their foraging efforts toward collecting pollen or nectar. Efforts to explain the origins of foraging specialization suggest that division of labor between nectar and pollen foraging specialists is influenced by genes with effects on reproductive physiology. Quantitative trait loci (QTL) mapping of foraging behavior also reveals candidate genes for reproductive traits. Here, we address the linkage of reproductive anatomy to behavior, using backcross QTL analysis, behavioral and anatomical phenotyping, candidate gene expression studies, and backcross confirmation of gene-to-anatomical trait associations. Our data show for the first time that the activity of two positional candidate genes for behavior, PDK1 and HR46, have direct genetic relationships to ovary size, a central reproductive trait that correlates with the nectar and pollen foraging bias of workers. These findings implicate two genes that were not known previously to influence complex social behavior. Also, they outline how selection may have acted on gene networks that affect reproductive resource allocation and behavior to facilitate the evolution of social foraging in honey bees.
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影响因子：
64.8
作者：
Amdam, GV;Csondes, A;Page, RE
通讯作者：
Page, RE
影响因子：
3.6
作者：
Capella, ICS;Hartfelder, K
通讯作者：
Hartfelder, K
影响因子：
2.3
作者：
CALDERONE, NW;PAGE, RE
通讯作者：
PAGE, RE
影响因子：
2.7
作者：
Drummond-Barbosa, D;Spradling, AC
通讯作者：
Spradling, AC
DOI：
10.1073/pnas.0403073101
发表时间：
2004-08-03
影响因子：
11.1
作者：
Amdam, GV;Norberg, K;Page, RE
通讯作者：
Page, RE