Large enhancement of canine taste responses to sugars by salts.
Large enhancement of canine taste responses to sugars by salts.
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DOI：
10.1085/jgp.95.5.1007
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发表时间：
1990-05
影响因子：
3.8
通讯作者：
KURIHARA, K
中科院分区：
文献类型：
--
作者：
KUMAZAWA, T;KURIHARA, K
通过记录鼓索神经的活动，研究了改变离子环境对犬对糖的味觉反应的影响。a）对各种糖的响应通过具有单价阳离子如Na+、K+、胆碱+或Tris+的盐的存在而大大增强。对糖的反应被高浓度的盐抑制。(b)果糖溶液中存在100 mM NaCl并不影响最大响应，并将浓度-响应关系的Hill常数从1.3变为2.4。(c)CaCl 2大大增强了对果糖的响应，而MgCl 2几乎没有表现出任何效果。20 mM CaCl 2在果糖溶液中的存在下，希尔常数从1.2变为2.4。(d)CaCl 2抑制了对0.5 M糖（果糖和蔗糖除外）的反应，并增强了对1 M所有糖的反应。在葡萄糖响应中，浓度-响应曲线的斜率因CaCl 2的存在而增加。在此，不存在CaCl 2时的曲线与存在CaCl 2时的曲线重合，表明CaCl 2抑制对低浓度葡萄糖的反应，并增强对高浓度葡萄糖的反应。(e)盐对糖反应的增强不能简单地用味细胞顶膜的离子渗透性来解释。盐对糖反应的增强和抑制作用被解释为糖受体分子之间的协同性。
The effects of changed ionic environments on the canine taste responses to sugars were examined by recording the activity of the chorda tympani nerve. a) The responses to various sugars were greatly enhanced by the presence of salts having monovalent cations such as Na+, K+, choline+, or Tris+. The responses to sugars were suppressed by high concentrations of salts. (b) The presence of 100 mM NaCl in fructose solution did not affect the maximal response and changed the Hill constant for the concentration-response relationship from 1.3 to 2.4. (c) CaCl2 greatly enhanced the response to fructose, while MgCl2 exhibited practically no effect. The presence of 20 mM CaCl2 in fructose solution changed the Hill constant from 1.2 to 2.4. (d) CaCl2 suppressed the responses to 0.5 M sugars except for fructose and sucrose and enhanced the responses to all sugars examined at 1 M. In the glucose response, the slope of the concentration-response curve was increased by the presence of CaCl2. Here the curve in the absence of CaCl2 intersected with that in the presence of CaCl2, indicating that CaCl2 suppressed the response to glucose of low concentrations and enhanced that of high concentrations. (e) The enhancement of the sugar responses by salts was not simply explained in terms of ionic permeability at the apical membranes of taste cells. The enhanced and suppressed effects of salts on the sugar responses were interpreted in terms of the cooperativity between receptor molecules for sugars.
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糖激活的离子转运在犬舌上皮中。对糖味转移的影响。
影响因子：
3.8
作者：
Mierson, S;DeSimone, S K;Heck, G L;DeSimone, J A
通讯作者：
DeSimone, J A
影响因子：
64.8
作者：
AVENET, P;HOFMANN, F;LINDEMANN, B
通讯作者：
LINDEMANN, B
影响因子：
--
作者：
SIMON, SA;LABARCA, P;ROBB, R
通讯作者：
ROBB, R
影响因子：
3.8
作者：
KIJIMA, H;NAGATA, K;MORITA, H
通讯作者：
MORITA, H
DOI：
10.1016/0005-2736(76)90412-0
发表时间：
1976-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
MIYAKE, M;KAMO, N;KOBATAKE, Y
通讯作者：
KOBATAKE, Y