Association of serum creatinine with aortic arch calcification in middle-aged and elderly adults: an observational cross-sectional study from China.
Association of serum creatinine with aortic arch calcification in middle-aged and elderly adults: an observational cross-sectional study from China.
复制标题
DOI：
10.1186/s12872-022-02617-6
复制
发表时间：
2022-04-12
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
--
作者：
血管钙化（VC）是心血管事件和心血管疾病（CVD）全因死亡率的重要预测因子。肾功能不全与VC密切相关。血清肌酐作为慢性肾病（CKD）患者肾功能的重要指标，与VC升高密切相关。在这里，为了探索血清肌酐在心血管疾病中的潜在作用，我们在更大的普通人群中检测了血清肌酐水平与主动脉弓钙化（AAC）存在之间的关系。本研究共纳入9067名年龄在0 ~ 45岁之间的参与者。所有参与者都进行了胸片后前方检查以诊断AAC。根据分布特点，将男性和女性血清肌酐水平分别分为三类。采用单因素和多因素logistic回归分析主动脉钙化与血清肌酐的关系。参与者包括3776名男性和5291名女性，分别检测到611名和990名AAC。女性AAC组血清肌酐水平显著高于非AAC组（p < 0.001），而男性两组血清肌酐水平差异无统计学意义（p = 0.241）。经logistic回归分析排除混杂因素后，以血清肌酐第一分位数为参照，多变量校正后女性和男性第二分位数、最高分位数的or和95% ci分别为1.045（0.856-1.276）、1.263 (1.036-1.539)；分别为0.953（0.761-1.193）、0.948（0.741-1.198）。血清肌酐水平升高与45岁女性AAC发病率升高独立相关。测定血清肌酐水平可以帮助早期筛查心血管疾病高危人群。在日常临床实践中应高度重视女性血清肌酐水平。在线版本包含补充材料，可在10.1186/s12872-022-02617-6获得。
Vascular calcification (VC) is a strong predictor of cardiovascular events and all-cause mortality in cardiovascular diseases (CVD). Renal dysfunction is closely related to VC. Serum creatinine, as an important indicator of renal function in chronic kidney disease (CKD), is closely associated with increased VC. Here, to explore the potential role of serum creatinine in CVD, we examined the association between serum creatinine level and aortic arch calcification (AAC) presence in a larger general population. A total of 9067 participants aged > 45 years were included in this study. All participants underwent postero-anterior chest X-ray examination to diagnose AAC. According to the distribution characteristics, serum creatinine levels in male and female were divided into tertiles respectively. Univariate and multivariate logistic regression analysis were used to analyze the association between aortic calcification and serum creatinine. Participants included 3776 men and 5291 women, and 611 and 990 AAC were detected, respectively. Serum creatinine level in the female AAC group was significantly higher than that in the non-AAC group (p < 0.001), while there was no significant difference in male serum creatinine between the two groups (p = 0.241). After logistic regression analysis excluded confounding factors, with the first tertile of serum creatinine as the reference, multivariable-adjusted ORs and 95% CIs of the second and the highest tertile of female and male were 1.045 (0.856–1.276), 1.263 (1.036–1.539); 0.953 (0.761–1.193), 0.948 (0.741–1.198), respectively. Elevated serum creatinine levels are independently associated with higher AAC incidence in female aged > 45 years old. Measuring serum creatinine levels may assist the early screening individuals at high risk of developing CVD. And higher attention should be given to female's serum creatinine levels in daily clinical practice. The online version contains supplementary material available at 10.1186/s12872-022-02617-6.
登录
查看更多内容
DOI：
10.2215/cjn.00840208
发表时间：
2008-11-01
影响因子：
9.8
作者：
Groesbeck, Darcy;Koettgen, Anna;Furth, Susan
通讯作者：
Furth, Susan
影响因子：
7.8
作者：
Purde, Mette-Triin;Nock, Stefan;Risch, Martin
通讯作者：
Risch, Martin
DOI：
10.1038/s41569-018-0064-2
发表时间：
2018-09
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Ferrucci L;Fabbri E
通讯作者：
Fabbri E
影响因子：
5.4
作者：
Park S;Cho NJ;Heo NH;Rhee EJ;Gil H;Lee EY
通讯作者：
Lee EY
影响因子：
5.3
作者：
Kim, Hyoungnae;Park, Jung Tak;Han, Seung Hyeok
通讯作者：
Han, Seung Hyeok