Plant Mitochondrial Inner Membrane Protein Insertion.

Plant Mitochondrial Inner Membrane Protein Insertion.
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DOI:
10.3390/ijms19020641
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发表时间:
2018-02-24
影响因子:
5.6
通讯作者:
Carrie C
Carrie C
中科院分区:
生物学2区
文献类型:
--
作者:
Kolli R;Soll J;Carrie C

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在线粒体内膜的生物发生过程中,大多数核编码的内膜蛋白在进入线粒体的过程中被TIM23和TIM22机械横向释放到膜上。一组核编码的线粒体内膜蛋白和所有线粒体编码的内膜蛋白都使用OxA机制--这种机制在进化上是从线粒体的内共生细菌祖先进化而来的--用于膜插入。与其他真核生物的线粒体相比,植物线粒体具有一些独特的特征,如更大的基因组和分支的电子传递途径,还参与了额外的细胞功能,如光呼吸和逆境感知。这篇综述着重于植物线粒体内膜蛋白插入机制的独特方面,它不同于酵母和人类,并包括一个关于COX2在酵母、人类、两种植物和一种藻类中的生物发生的案例研究,以突出特定谱系的相似性和差异性。有趣的是,与其他真核生物的线粒体不同,但与细菌和叶绿体相似,植物线粒体似乎使用TAT机制来插入Rieske Fe/S蛋白的膜。
During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the Oxa machinery—which is evolutionarily conserved from the endosymbiotic bacterial ancestor of mitochondria—for membrane insertion. Compared to the mitochondria from other eukaryotes, plant mitochondria have several unique features, such as a larger genome and a branched electron transport pathway, and are also involved in additional cellular functions such as photorespiration and stress perception. This review focuses on the unique aspects of plant mitochondrial inner membrane protein insertion machinery, which differs from that in yeast and humans, and includes a case study on the biogenesis of Cox2 in yeast, humans, two plant species, and an algal species to highlight lineage-specific similarities and differences. Interestingly, unlike mitochondria of other eukaryotes but similar to bacteria and chloroplasts, plant mitochondria appear to use the Tat machinery for membrane insertion of the Rieske Fe/S protein.
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