An in silico analysis of the mitochondrial protein import apparatus of plants.
An in silico analysis of the mitochondrial protein import apparatus of plants.
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DOI：
10.1186/1471-2229-10-249
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发表时间：
2010-11-16
影响因子：
5.3
通讯作者：
Whelan J
中科院分区：
文献类型：
--
作者：
Carrie C;Murcha MW;Whelan J
对来自各种物种的线粒体蛋白质输入装置进行计算机分析，包括莱茵衣藻、小球藻、硅化外果藻、Cyanidioschyzon merolae、小立碗藓、卷柏、云杉、水稻和拟南芥，以确定植物和非植物物种内和之间的组分是否不同。外膜元件Tom 40和Sam 50的通道形成亚基在植物类群和其他真核生物之间是保守的。相反，在绿色植物，特别是Tom 20（C. reinhardtii，C. variabilis、P. patens、S. moellendorffii、灰绿拟步行虫P. glauca、O. sativa和A. thaliana）是这一谱系特有的。红藻含有一个与酵母Tom 22直接相连的Tom 22受体。此外，植物线粒体受体显示不同植物谱系之间的差异。这些通过在所有植物Metaxins中的独特基序（其在红藻中不存在）以及在被子植物（水稻和拟南芥）中而不是在石松植物中存在外膜受体OM 64来证明（S. moellendorffii）和裸子植物（P. glauca）。此外，虽然膜间隙受体Mia 40在广泛的系统发育范围内是保守的，但其功能在谱系之间不同。在所有植物谱系中，Tim 17含有C-末端延伸，其可作为将核酸输入到植物线粒体中的受体组分。有人提出，所观察到的功能分歧是由于选择压力，以排序蛋白质之间的线粒体和叶绿体，导致在植物群体和其他生物体之间的蛋白质受体成分的差异。此外，在植物界内观察到受体组分的多样性。即使当受体成分在植物和非植物物种中是同源的，这些受体的功能似乎也以谱系特异性的方式扩展或分化。
An in silico analysis of the mitochondrial protein import apparatus from a variety of species; including Chlamydomonas reinhardtii, Chlorella variabilis, Ectocarpus siliculosus, Cyanidioschyzon merolae, Physcomitrella patens, Selaginella moellendorffii, Picea glauca, Oryza sativa and Arabidopsis thaliana was undertaken to determine if components differed within and between plant and non-plant species. The channel forming subunits of the outer membrane components Tom40 and Sam50 are conserved between plant groups and other eukaryotes. In contrast, the receptor component(s) in green plants, particularly Tom20, (C. reinhardtii, C. variabilis, P. patens, S. moellendorffii, P. glauca, O. sativa and A. thaliana) are specific to this lineage. Red algae contain a Tom22 receptor that is orthologous to yeast Tom22. Furthermore, plant mitochondrial receptors display differences between various plant lineages. These are evidenced by distinctive motifs in all plant Metaxins, which are absent in red algae, and the presence of the outer membrane receptor OM64 in Angiosperms (rice and Arabidopsis), but not in lycophytes (S. moellendorffii) and gymnosperms (P. glauca). Furthermore, although the intermembrane space receptor Mia40 is conserved across a wide phylogenetic range, its function differs between lineages. In all plant lineages, Tim17 contains a C-terminal extension, which may act as a receptor component for the import of nucleic acids into plant mitochondria. It is proposed that the observed functional divergences are due to the selective pressure to sort proteins between mitochondria and chloroplasts, resulting in differences in protein receptor components between plant groups and other organisms. Additionally, diversity of receptor components is observed within the plant kingdom. Even when receptor components are orthologous across plant and non-plant species, it appears that the functions of these have expanded or diverged in a lineage specific manner.
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影响因子：
64.8
作者：
Matsumoto, T;Wu, JZ;Sugiura, M
通讯作者：
Sugiura, M
DOI：
10.1073/pnas.0908264106
发表时间：
2009-09-15
影响因子：
11.1
作者：
Clements, Abigail;Bursac, Dejan;Lithgow, Trevor
通讯作者：
Lithgow, Trevor
影响因子：
7.7
作者：
Bhushan, S;Lefebvre, B;Glaser, E
通讯作者：
Glaser, E
影响因子：
3.5
作者：
Chew, O;Lister, R;Whelan, J
通讯作者：
Whelan, J
DOI：
10.1093/protein/10.6.673
发表时间：
1997-06-01
期刊：
PROTEIN ENGINEERING
影响因子：
--
作者：
Cserzo, M;Wallin, E;Elofsson, A
通讯作者：
Elofsson, A