Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells.
Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells.
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DOI：
10.1155/2021/4910816
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发表时间：
2021
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Lu D;Liu Y;Li W;Ma H;Li T;Ma X;Mao Y;Liang Q;Ma Z;Wang J
三维（3D）生物打印是一项革命性的技术，通过控制生物材料的逐层沉积，在体外复制3D功能活组织支架，并实现细胞的高度精确定位。随着该技术的发展，可能会对组织形态发生、临床药物筛选和器官再生的机制进行更深入的研究。诱导多能干细胞（induced pluripotent stem cells，iPSCs）具有自我更新和多向分化潜能，在干细胞研究和应用中具有突出的优势。在这篇综述中，我们讨论了通过3D生物打印制造的含有人类iPSC的不同生物墨水的优点。特别是，我们专注于这些生物墨水支持iPSC并促进其增殖和分化的能力。最后，总结了含iPSC的生物墨水在3D生物打印中的应用，并对目前的研究现状提出了新的看法。
Three-dimensional (3D) bioprinting is a revolutionary technology that replicates 3D functional living tissue scaffolds in vitro by controlling the layer-by-layer deposition of biomaterials and enables highly precise positioning of cells. With the development of this technology, more advanced research on the mechanisms of tissue morphogenesis, clinical drug screening, and organ regeneration may be pursued. Because of their self-renewal characteristics and multidirectional differentiation potential, induced pluripotent stem cells (iPSCs) have outstanding advantages in stem cell research and applications. In this review, we discuss the advantages of different bioinks containing human iPSCs that are fabricated by using 3D bioprinting. In particular, we focus on the ability of these bioinks to support iPSCs and promote their proliferation and differentiation. In addition, we summarize the applications of 3D bioprinting with iPSC-containing bioinks and put forward new views on the current research status.
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影响因子：
5
作者：
Cho S;Lee C;Skylar-Scott MA;Heilshorn SC;Wu JC
通讯作者：
Wu JC
影响因子：
14
作者：
Kerscher P;Turnbull IC;Hodge AJ;Kim J;Seliktar D;Easley CJ;Costa KD;Lipke EA
通讯作者：
Lipke EA
影响因子：
20.1
作者：
Gao L;Kupfer ME;Jung JP;Yang L;Zhang P;Da Sie Y;Tran Q;Ajeti V;Freeman BT;Fast VG;Campagnola PJ;Ogle BM;Zhang J
通讯作者：
Zhang J
影响因子：
5.8
作者：
Abelseth, Emily;Abelseth, Laila;Willerth, Stephanie M.
通讯作者：
Willerth, Stephanie M.
影响因子：
2.7
作者：
de la Vega, Laura;Rosas Gomez, Diego A.;Willerth, Stephanie M.
通讯作者：
Willerth, Stephanie M.