Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications.
Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications.
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DOI：
10.3390/ma10040334
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发表时间：
2017-03-24
期刊：
影响因子：
--
通讯作者：
Metoki N
中科院分区：
文献类型：
--
作者：
Eliaz N;Metoki N
磷酸钙生物陶瓷具有良好的生物相容性、骨整合性和骨传导性，广泛应用于骨科和牙科的骨再生领域。本文的目的是回顾这些材料的历史，结构，性能和临床应用，无论是骨水泥，浆料，支架还是涂层。本文还总结了CaP的主要分析技术、体外和体内试验、美国食品和药物管理局（FDA）和国际标准对CaP涂层在骨科和牙科内种植体上的要求，以及灭菌对这些材料可能产生的影响。综述了CaP涂层技术，重点介绍了电化学工艺。讨论了生物矿化过程中瞬态前体相的形成、溶出和再沉淀机理。介绍了各种各样的CaP，从单个相到纳米CaP，双相和三相CaP配方，复合CaP涂层和水泥，功能梯度材料（fgm）和抗菌CaP。最后，我们展望了cap的未来。
Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials. CaP coating technologies are summarized, with a focus on electrochemical processes. Theories on the formation of transient precursor phases in biomineralization, the dissolution and reprecipitation as bone of CaPs are discussed. A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs. We conclude by foreseeing the future of CaPs.
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影响因子：
4.8
作者：
Allo BA;Costa DO;Dixon SJ;Mequanint K;Rizkalla AS
通讯作者：
Rizkalla AS
影响因子：
14
作者：
Alt, V;Bechert, T;Schnettler, R
通讯作者：
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DOI：
10.1016/0166-6622(90)80221-o
发表时间：
1990-09-01
期刊：
COLLOIDS AND SURFACES
影响因子：
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作者：
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通讯作者：
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DOI：
10.1524/zkri.2012.1524
发表时间：
2012-01-01
影响因子：
1.2
作者：
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通讯作者：
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DOI：
10.1007/s10856-006-0439-5
发表时间：
2006-11-01
影响因子：
3.7
作者：
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通讯作者：
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